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Ishak D. Irwan
Researcher at Agency for Science, Technology and Research
Publications - 9
Citations - 531
Ishak D. Irwan is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Population & Allelic heterogeneity. The author has an hindex of 6, co-authored 7 publications receiving 446 citations.
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Journal ArticleDOI
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
Xianyong Yin,Hui Qi Low,Ling Wang,Yonghong Li,Eva Ellinghaus,Jiali Han,Xavier Estivill,Liangdan Sun,Xianbo Zuo,Changbing Shen,Caihong Zhu,Anping Zhang,Fabio Sánchez,Leonid Padyukov,Joseph J. Catanese,Gerald G. Krueger,Kristina Callis Duffin,Sören Mucha,Michael Weichenthal,Stephan Weidinger,Wolfgang Lieb,Jia Nee Foo,Yi Li,Kar Seng Sim,Herty Liany,Ishak D. Irwan,Yik-Ying Teo,Colin Theng,Rashmi Gupta,Anne M. Bowcock,Philip L. De Jager,Philip L. De Jager,Abrar A. Qureshi,Abrar A. Qureshi,Paul I.W. de Bakker,Mark Seielstad,Mark Seielstad,Wilson Liao,Mona Ståhle,Andre Franke,Xuejun Zhang,Jianjun Liu,Jianjun Liu +42 more
TL;DR: This study presents the largest trans-ethnic genome-wide meta-analysis of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries and suggests population-specific effect or allelic heterogeneity for 11 loci.
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
Xianyong Yin,Hui Qi Low,Ling Wang,Yonghong Li,Eva Ellinghaus,Jiali Han,Xavier Estivill,Liangdan Sun,Xianbo Zuo,Changbing Shen,Caihong Zhu,Anping Zhang,Fabio Sánchez,Leonid Padyukov,Joseph J. Catanese,Gerald G. Krueger,Kristina Callis Duffin,Sören Mucha,Michael Weichenthal,Stephan Weidinger,Wolfgang Lieb,Jia Nee Foo,Yi Li,Kar Seng Sim,Herty Liany,Ishak D. Irwan,Yik-Ying Teo,Colin Theng,Rashmi Gupta,Anne M. Bowcock,Philip L. De Jager,Philip L. De Jager,Abrar A. Qureshi,Abrar A. Qureshi,Paul I.W. de Bakker,Mark Seielstad,Mark Seielstad,Wilson Liao,Mona Ståhle,Andre Franke,Xuejun Zhang,Jianjun Liu,Jianjun Liu +42 more
TL;DR: In this paper, the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries was presented.
Journal ArticleDOI
GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-Cell Lymphoma
Karin E. Smedby,Jia Nee Foo,Christine F. Skibola,Hatef Darabi,Lucia Conde,Henrik Hjalgrim,Vikrant Kumar,Ellen T. Chang,Ellen T. Chang,Nathaniel Rothman,James R. Cerhan,Angela Brooks-Wilson,Angela Brooks-Wilson,Emil Rehnberg,Ishak D. Irwan,Lars P. Ryder,Peter de Nully Brown,Paige M. Bracci,Luz Agana,Jacques Riby,Wendy Cozen,Scott Davis,Scott Davis,Patricia Hartge,Lindsay M. Morton,Richard K. Severson,Sophia S. Wang,Sophia S. Wang,Susan L. Slager,Zachary S. Fredericksen,Anne J. Novak,Neil E. Kay,Thomas M. Habermann,Bruce K. Armstrong,Anne Kricker,Sam Milliken,Mark P. Purdue,Claire M. Vajdic,Peter Boyle,Qing Lan,Shelia Hoar Zahm,Yawei Zhang,Tongzhang Zheng,Stephen Leach,John J. Spinelli,Martyn T. Smith,Stephen J. Chanock,Leonid Padyukov,Lars Alfredsson,Lars Klareskog,Bengt Glimelius,Bengt Glimelius,Mads Melbye,Edison T. Liu,Hans-Olov Adami,Hans-Olov Adami,Keith Humphreys,Jianjun Liu +57 more
TL;DR: The results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma.
Journal ArticleDOI
Identification of new susceptibility loci for IgA nephropathy in Han Chinese
Ming Li,Jia Nee Foo,Jin Quan Wang,Hui Qi Low,Xue Qing Tang,Kai Yee Toh,Pei Ran Yin,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Yu Fen Goh,Ishak D. Irwan,Ri Cong Xu,Anand Kumar Andiappan,Jin Xin Bei,Olaf Rötzschke,Meng-Hua Chen,Ching-Yu Cheng,Ching-Yu Cheng,Liangdan Sun,Geng Ru Jiang,Tien Yin Wong,Tien Yin Wong,Hong Li Lin,Tin Aung,Tin Aung,Yun Hua Liao,Seang-Mei Saw,Seang-Mei Saw,Kun Ye,Richard P. Ebstein,Qin Kai Chen,Wei Shi,Soo Hong Chew,Jian Chen,Fu Ren Zhang,Shengping Li,Gang Xu,E. Shyong Tai,Li Wang,Nan Chen,Xuejun Zhang,Yi Xin Zeng,Hong Zhang,Zhihong Liu,Xueqing Yu,Jianjun Liu,Jianjun Liu,Jianjun Liu +48 more
TL;DR: The findings expand the understanding on IgAN genetic susceptibility and provide novel biological insights into molecular mechanisms underlying IgAN, and correlate with geographical variation in IgAN prevalence.
Journal ArticleDOI
Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk.
Jia Nee Foo,Karin E. Smedby,Nicholas K. Akers,Mattias Berglund,Ishak D. Irwan,Xiaoming Jia,Xiaoming Jia,Yi Li,Lucia Conde,Hatef Darabi,Paige M. Bracci,Mads Melbye,Hans-Olov Adami,Hans-Olov Adami,Bengt Glimelius,Chiea Chuen Khor,Henrik Hjalgrim,Leonid Padyukov,Keith Humphreys,Gunilla Enblad,Christine F. Skibola,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jianjun Liu,Jianjun Liu +25 more
TL;DR: A hexa-allelic amino acid polymorphism at position 13 of the HLA-DR beta chain that showed the strongest association with FL within the major histocompatibility complex (MHC) region is identified and might explain the complex SNP associations identified by GWASs and suggests a common HLA -DR antigen-driven mechanism for the pathogenesis of FL and rheumatoid arthritis.