J
J. Erby Wilkinson
Researcher at University of Michigan
Publications - 18
Citations - 5763
J. Erby Wilkinson is an academic researcher from University of Michigan. The author has contributed to research in topics: Metastasis & PI3K/AKT/mTOR pathway. The author has an hindex of 14, co-authored 18 publications receiving 4961 citations.
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Journal ArticleDOI
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison,Randy Strong,Zelton D Sharp,James F. Nelson,Clinton M. Astle,Kevin Flurkey,Nancy L. Nadon,J. Erby Wilkinson,Krystyna Frenkel,Christy S. Carter,Christy S. Carter,Marco Pahor,Marco Pahor,Martin A. Javors,Elizabeth Fernandez,Richard A. Miller +15 more
TL;DR: It is reported that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.
Journal ArticleDOI
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Richard A. Miller,Richard A. Miller,David E. Harrison,Clinton M. Astle,Joseph A. Baur,Angela R. Boyd,Rafael de Cabo,Elizabeth Fernandez,Kevin Flurkey,Martin A. Javors,James F. Nelson,Carlos J. Orihuela,Scott D. Pletcher,Zelton D Sharp,David A. Sinclair,Joseph W. Starnes,J. Erby Wilkinson,Nancy L. Nadon,Randy Strong +18 more
TL;DR: Evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target ofRapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.
Journal ArticleDOI
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
Gayatri Arun,Sarah D. Diermeier,Martin Akerman,Kung-Chi Chang,Kung-Chi Chang,J. Erby Wilkinson,Stephen Hearn,Youngsoo Kim,A. Robert MacLeod,Adrian R. Krainer,Adrian R. Krainer,Larry Norton,Edi Brogi,Mikala Egeblad,David L. Spector,David L. Spector +15 more
TL;DR: It is reported that genetic loss or systemic knockdown of Malat1 using antisense oligonucleotides (ASOs) in the MMTV-PyMT- and Her2/neu-amplified tumor organoids model results in slower tumor growth accompanied by significant differentiation into cystic tumors and a reduction in metastasis.
Journal ArticleDOI
Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
David E. Harrison,Randy Strong,David B. Allison,Bruce N. Ames,Clinton M. Astle,Hani Atamna,Elizabeth Fernandez,Kevin Flurkey,Martin A. Javors,Nancy L. Nadon,James F. Nelson,Scott D. Pletcher,James W. Simpkins,Daniel L. Smith,J. Erby Wilkinson,Richard A. Miller +15 more
TL;DR: New pharmacological models for exploring processes that regulate the timing of aging and late‐life diseases are provided, and in particular for testing hypotheses about sexual dimorphism in aging and health are tested.
Journal ArticleDOI
A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression
Nobuhiro Okada,Chao Po Lin,Marcelo C. Ribeiro,Anne Biton,Gregory Lai,Xingyue He,Pengcheng Bu,Hannes Vogel,David M. Jablons,Andreas Keller,Andreas Keller,J. Erby Wilkinson,Biao He,Terry P. Speed,Lin He +14 more
TL;DR: The results elucidated the intricate cross-talk between p53 and miR-34 miRNAs and revealed an important tumor suppressor effect generated by this positive feedback loop.