J. F. Gagnon

TL;DR: The psychological characteristics of a large cohort of patients with DM1 are described to characterize those at risk of developing a psychiatric disorder, and to compare characteristics between two DM1 phenotypes, a mild and more severe adult‐onset phenotype.

TL;DR: This paper performed a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB2.

TL;DR: In this paper , the authors used linear mixed-effect modeling to estimate annual rates of clinical marker progression stratified by disease subtype, including prodromal Parkinson's disease and dementia with Lewy bodies, and calculated sample size requirements to demonstrate slowing of progression under different anticipated treatment effects.

TL;DR: It is demonstrated that the development of atrophy in synucleinopathies is constrained by specific genes and networks, and thinning in iRBD was constrained by the brain's connectome and that it mapped onto specific networks involved in motor and planning functions.

TL;DR: In this paper , the authors performed cutting-edge imaging transcriptomics and comprehensive spatial mapping analyses in a multicentric cohort of 171 polysomnography-confirmed isolated rapid eye movement sleep behaviour disorder (iRBD) patients (67.7 ± 6.6 (49-87) years; 83% men) and 238 healthy controls (66.6 ± 7.9 (41-88) years).