Paul Cannon

TL;DR: The overall Parkinson's disease genetic risk score modifies risk for disease and decreases age at onset in carriers of GBA variants, and common variability at genes implicated in lysosomal function exerts the largest effect on GBA associatedrisk for disease.

TL;DR: In this article, the authors systematically analyzed pLoF variants in LRRK2 observed across 141,456 individuals sequenced in the Genome Aggregation Database (gnomAD)9, 49,960 exome-sequenced individuals from the UK Biobank and over 4 million participants in the 23andMe genotyped dataset.

TL;DR: Across the studies included in this review, there was a positive association with psychosocial health if patients returned to employment, which included improved health related quality of life and fewer depressive symptoms.

TL;DR: An in‐depth analysis of the SNCA locus was performed to identify RBD‐specific risk variants and found three novel mechanisms leading to prodromal synucleinopathy.

TL;DR: This work performed the first genome-wide association study of Latino PD patients from South America, demonstrating that SNCA plays a significant role in PD etiology in a Latino cohort and identifying a suggestive locus near NRROS on chromosome 3 that appeared to be driven by Peruvian subjects.