J
Jackson Emanuel
Researcher at Humboldt University of Berlin
Publications - 3
Citations - 263
Jackson Emanuel is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Autophagy & BECN1. The author has an hindex of 2, co-authored 3 publications receiving 119 citations. Previous affiliations of Jackson Emanuel include Charité.
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Journal ArticleDOI
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Jackson Emanuel,Jackson Emanuel,Frederik Dethloff,Robert Lorenz Chua,Jakob Trimpert,Nicolas Heinemann,Nicolas Heinemann,Christine Niemeyer,Friderike Weege,Friderike Weege,Katja Hönzke,Tom Aschman,Daniel E. Heinz,Katja Weckmann,Tim Ebert,Andreas Zellner,M. Lennarz,Emanuel Wyler,Simon Schroeder,Simon Schroeder,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Karen Hoffmann,Thomas F. Meyer,Frank L. Heppner,Frank L. Heppner,Victor M. Corman,Victor M. Corman,Markus Landthaler,Markus Landthaler,Andreas C. Hocke,Markus Morkel,Markus Morkel,Nikolaus Osterrieder,Nikolaus Osterrieder,Christian Conrad,Roland Eils,Roland Eils,Helena Radbruch,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller +48 more
TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Posted ContentDOI
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Frederik Dethloff,Jackson Emanuel,Jackson Emanuel,Katja Weckmann,Daniel E. Heinz,Nicolas Heinemann,Nicolas Heinemann,M. Lennarz,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Victor M. Corman,Victor M. Corman,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller,Marcel A. Müller +22 more
TL;DR: It is shown that SARS-CoV-2 infection limits autophagy by interfering with multiple metabolic pathways and that compound-driven interventions aimed at Autophagy induction reduce Sars-Cov-2 propagation in vitro.
Journal ArticleDOI
Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells.
Jan Papies,Jan Papies,Jackson Emanuel,Jackson Emanuel,Nicolas Heinemann,Nicolas Heinemann,Žarko Kulić,Simon Schroeder,Simon Schroeder,Beate Tenner,Martin D Lehner,Georg Seifert,Georg Seifert,Marcel A. Müller,Marcel A. Müller +14 more
TL;DR: In this paper, Pelargonium sidoides DC. root extract EPs 7630 has antiviral and immunomodulatory properties, limiting symptom severity and disease duration of infections with several upper respiratory viruses.