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Daniel E. Heinz
Researcher at University of Bonn
Publications - 4
Citations - 249
Daniel E. Heinz is an academic researcher from University of Bonn. The author has contributed to research in topics: Autophagy & BECN1. The author has an hindex of 2, co-authored 2 publications receiving 119 citations.
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Journal ArticleDOI
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Jackson Emanuel,Jackson Emanuel,Frederik Dethloff,Robert Lorenz Chua,Jakob Trimpert,Nicolas Heinemann,Nicolas Heinemann,Christine Niemeyer,Friderike Weege,Friderike Weege,Katja Hönzke,Tom Aschman,Daniel E. Heinz,Katja Weckmann,Tim Ebert,Andreas Zellner,M. Lennarz,Emanuel Wyler,Simon Schroeder,Simon Schroeder,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Karen Hoffmann,Thomas F. Meyer,Frank L. Heppner,Frank L. Heppner,Victor M. Corman,Victor M. Corman,Markus Landthaler,Markus Landthaler,Andreas C. Hocke,Markus Morkel,Markus Morkel,Nikolaus Osterrieder,Nikolaus Osterrieder,Christian Conrad,Roland Eils,Roland Eils,Helena Radbruch,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller +48 more
TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Posted ContentDOI
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Frederik Dethloff,Jackson Emanuel,Jackson Emanuel,Katja Weckmann,Daniel E. Heinz,Nicolas Heinemann,Nicolas Heinemann,M. Lennarz,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Victor M. Corman,Victor M. Corman,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller,Marcel A. Müller +22 more
TL;DR: It is shown that SARS-CoV-2 infection limits autophagy by interfering with multiple metabolic pathways and that compound-driven interventions aimed at Autophagy induction reduce Sars-Cov-2 propagation in vitro.
Posted ContentDOI
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
Jakob Hartmann,Thomas Bajaj,Joy Otten,Claudia Klengel,Anne-Kathrin Gellner,E. Junglas,Kathrin Hafner,Elmira Anderzhanova,Fiona Tang,Galen Missig,Lindsay Rexrode,Max L. Pöhlmann,Daniel E. Heinz,Roy Lardenoije,Nina Dedic,Kenneth M. McCullough,Tomasz Próchnicki,Thomas A. Rhomberg,Silvia Martinelli,Antony Payton,Andrew C Robinson,Valentin Stein,Eicke Latz,William A. Carlezon,Mathias V. Schmidt,Chris Murgatroyd,Sabina Berretta,Torsten Klengel,Harry Pantazopoulos,Kerry J. Ressler,Nils C. Gassen +30 more
TL;DR: The authors showed that SKA2-regulated, hyperactive secretory autophagy facilitates neuroinflammation and is linked to Alzheimer's disease, providing new mechanistic insight into the biology of neuro inflammation.
Posted ContentDOI
A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice
Georgia Balsevich,Gavin N. Petrie,Daniel E. Heinz,Arashdeep Singh,Robert J. Aukema,Avery C. Hunker,Haley A. Vecchiarelli,Hiulan Yau,Martin A. Sticht,Roger J. Thompson,Francis S. Lee,Larry S. Zweifel,Prasanth K. Chelikani,Nils C. Gassen,Matthew N. Hill +14 more
TL;DR: Together, the FAAH A/A genotype amplifies orexigenic responses and decreases anorexigenics responses, providing a putative mechanism explaining the diverging human findings.