J
James J L Hodge
Researcher at University of Bristol
Publications - 57
Citations - 1809
James J L Hodge is an academic researcher from University of Bristol. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 21, co-authored 52 publications receiving 1446 citations. Previous affiliations of James J L Hodge include Brandeis University & Queen Mary University of London.
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Journal ArticleDOI
PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit
Katherine M. Parisky,Jose Agosto,Jose Agosto,Stefan R. Pulver,Yuhua Shang,Yuhua Shang,Elena A. Kuklin,James J L Hodge,KyeongJin Kang,Xu Liu,Paul A. Garrity,Michael Rosbash,Michael Rosbash,Leslie C. Griffith +13 more
TL;DR: These features of the Drosophila sleep circuit, GABAergic control of onset and maintenance as well as peptidergic control of arousal, support the idea that features of sleep-circuit architecture aswell as the mechanisms governing the behavioral transitions between sleep and wake are conserved between mammals and insects.
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Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature.
Chenghao Chen,Edgar Buhl,Min Xu,Vincent Croset,Johanna S. Rees,Kathryn S. Lilley,Richard Benton,James J L Hodge,Ralf Stanewsky +8 more
TL;DR: It is shown that Drosophila Ionotropic Receptor 25a (IR25a) is required for behavioural synchronization to low-amplitude temperature cycles, and it is proposed that IR25a is part of an input pathway to the circadian clock that detects small temperature differences.
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Regulation of the Ca2+/CaM-Responsive Pool of CaMKII by Scaffold-Dependent Autophosphorylation
TL;DR: Cmg, the Drosophila homolog of CASK/Lin-2, associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMK II, which provides a mechanism by which the active postsynaptic pool of Ca MKII can be controlled locally to differentiate active and inactive synapses.
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The eag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II.
TL;DR: Activity-dependent binding to this potassium channel substrate allows CaMKII to remain locally active even when Ca2+ levels have dropped, providing a novel mechanism by which CaMK II can regulate excitability locally over long time scales.
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A Neural Network Underlying Circadian Entrainment and Photoperiodic Adjustment of Sleep and Activity in Drosophila.
Matthias Schlichting,Pamela Menegazzi,Katharine R. Lelito,Zepeng Yao,Edgar Buhl,Elena Dalla Benetta,Andrew Bahle,Jennifer Denike,James J L Hodge,Charlotte Helfrich-Förster,Orie T. Shafer +10 more
TL;DR: The results establish that input from the HB eyelets differentially impacts the physiology of neuronal subgroups, and provide a mechanistic model of light transduction and integration into the circadian system, identifying new and unexpected network motifs within the circadian clock neuron network.