J
James Nisbet
Researcher at Wellcome Trust Sanger Institute
Publications - 9
Citations - 1935
James Nisbet is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: DNA methylation & Quantitative trait locus. The author has an hindex of 7, co-authored 8 publications receiving 1745 citations.
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Journal ArticleDOI
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Jordana T. Bell,Pei-Chien Tsai,Tsun-Po Yang,Ruth Pidsley,James Nisbet,Daniel Glass,Massimo Mangino,Guangju Zhai,Guangju Zhai,Feng Zhang,Ana M. Valdes,So-Youn Shin,Emma Dempster,Robin M. Murray,Elin Grundberg,Elin Grundberg,Åsa K. Hedman,Alexandra C. Nica,Kerrin S. Small,Emmanouil T. Dermitzakis,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Jonathan Mill,Tim D. Spector,Panos Deloukas +25 more
TL;DR: The results suggest that in a small set of genes DNA methylation may be a candidate mechanism of mediating not only environmental, but also genetic effects on age-related phenotypes, and that a-DMRs may initiate at an earlier age.
Journal ArticleDOI
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study
Alexandra C. Nica,Alexandra C. Nica,Leopold Parts,Daniel Glass,James Nisbet,Amy Barrett,Magdalena Sekowska,Mary E. Travers,Simon C. Potter,Elin Grundberg,Elin Grundberg,Kerrin S. Small,Kerrin S. Small,Åsa K. Hedman,Veronique Bataille,Jordana T. Bell,Jordana T. Bell,Gabriela L. Surdulescu,Antigone S. Dimas,Antigone S. Dimas,Catherine E. Ingle,Frank O. Nestle,Paola Di Meglio,Josine L. Min,Alicja Wilk,Christopher J Hammond,N Hassanali,Tsun-Po Yang,Stephen B. Montgomery,S O'Rahilly,Cecilia M. Lindgren,Krina T. Zondervan,Nicole Soranzo,Nicole Soranzo,Inês Barroso,Inês Barroso,Richard Durbin,Kourosh R. Ahmadi,Panos Deloukas,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Emmanouil T. Dermitzakis,Tim D. Spector +43 more
TL;DR: The role of cis-regulatory variation in three human tissues: lymphoblastoid cell lines, skin, and fat is explored and it is proposed that continuous estimates of the proportion of tissue-shared signals and direct comparison of the magnitude of effect on the fold change in expression are essential properties that jointly provide a biologically realistic view of tissues-specificity.
Journal ArticleDOI
Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements
Elin Grundberg,Elin Grundberg,Eshwar Meduri,Eshwar Meduri,Johanna K. Sandling,Johanna K. Sandling,Johanna K. Sandling,Åsa K. Hedman,Sarah Keildson,Alfonso Buil,Stephan Busche,Wei Yuan,James Nisbet,Magdalena Sekowska,Alicja Wilk,Amy Barrett,Kerrin S. Small,Bing Ge,Maxime Caron,So-Youn Shin,Mark Lathrop,Emmanouil T. Dermitzakis,Mark I. McCarthy,Tim D. Spector,Jordana T. Bell,Panos Deloukas +25 more
TL;DR: The results showed widespread population invariability yet sequence dependence on adipose DNA methylation but that incorporating maps of regulatory elements aid in linking CpG variation to gene regulation and disease risk in a tissue-dependent manner.
Journal ArticleDOI
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation.
Loukia Tsaprouni,Tsun-Po Yang,Jordana T. Bell,Katherine J. Dick,Stavroula Kanoni,James Nisbet,Ana Viñuela,Elin Grundberg,Christopher P. Nelson,Eshwar Meduri,Alfonso Buil,François Cambien,Christian Hengstenberg,Jeanette Erdmann,Heribert Schunkert,Alison H. Goodall,Willem H. Ouwehand,Emmanouil T. Dermitzakis,Tim D. Spector,Nilesh J. Samani,Panos Deloukas +20 more
TL;DR: The findings suggest the existence of dynamic, reversible site-specific methylation changes in response to cigarette smoking, which may contribute to the extended health risks associated with cigarette smoking.
Journal ArticleDOI
Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.
Dirk S. Paul,James Nisbet,Tsun-Po Yang,Stuart Meacham,Stuart Meacham,Stuart Meacham,Augusto Rendon,Augusto Rendon,Augusto Rendon,Katta Hautaviita,Jonna Tallila,Jacqui White,Marloes R. Tijssen,Suthesh Sivapalaratnam,Hanneke Basart,Mieke D. Trip,Berthold Göttgens,Nicole Soranzo,Nicole Soranzo,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Panos Deloukas +22 more
TL;DR: The formaldehyde-assisted isolation of regulatory elements (FAIRE) method was applied in a megakaryocytic and an erythroblastoid cell line to map active regulatory elements at known loci associated with hematological quantitative traits, coronary artery disease, and myocardial infarction and suggested a molecular mechanism by which a non-coding GWA index SNP modulates platelet phenotype.