L
Loukia Tsaprouni
Researcher at Birmingham City University
Publications - 30
Citations - 3348
Loukia Tsaprouni is an academic researcher from Birmingham City University. The author has contributed to research in topics: Football & Medicine. The author has an hindex of 13, co-authored 24 publications receiving 2952 citations. Previous affiliations of Loukia Tsaprouni include University of Bedfordshire & RMIT University.
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Journal ArticleDOI
Mapping cis - and trans -regulatory effects across multiple tissues in twins
Elin Grundberg,Kerrin S. Small,Kerrin S. Small,Åsa K. Hedman,Alexandra C. Nica,Alfonso Buil,Sarah Keildson,Jordana T. Bell,Jordana T. Bell,Yang T-P.,Eshwar Meduri,Eshwar Meduri,Amy Barrett,James Nisbett,Magdalena Sekowska,Alicja Wilk,Shin S-Y.,Daniel Glass,Mary E. Travers,Josine L. Min,Susan M. Ring,Karen M Ho,Gudmar Thorleifsson,Augustine Kong,Unnur Thorsteindottir,Unnur Thorsteindottir,Chrysanthi Ainali,Antigone S. Dimas,Neelam Hassanali,Catherine E. Ingle,David A. Knowles,Maria Krestyaninova,Christopher E. Lowe,Christopher E. Lowe,P. Di Meglio,Stephen B. Montgomery,Stephen B. Montgomery,Leopold Parts,Simon C. Potter,Gabriela L. Surdulescu,Loukia Tsaprouni,Sophia Tsoka,Veronique Bataille,Richard Durbin,Frank O. Nestle,Stephen O'Rahilly,Stephen O'Rahilly,Nicole Soranzo,Cecilia M. Lindgren,Krina T. Zondervan,Kourosh R. Ahmadi,Eric E. Schadt,Kari Stefansson,Kari Stefansson,George Davey Smith,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Panos Deloukas,Emmanouil T. Dermitzakis,Tim D. Spector +60 more
TL;DR: It is shown that at least 40% of the total heritable cis effect on expression cannot be accounted for by common cis variants, a finding that reveals the contribution of low-frequency and rare regulatory variants with respect to both transcriptional regulation and complex trait susceptibility.
Journal ArticleDOI
DNA methylation and body-mass index: a genome-wide analysis
Katherine J. Dick,Katherine J. Dick,Christopher P. Nelson,Christopher P. Nelson,Loukia Tsaprouni,Johanna K. Sandling,Johanna K. Sandling,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Simone Wahl,Eshwar Meduri,Pierre-Emmanuel Morange,Harald Grallert,Melanie Waldenberger,Annette Peters,Jeanette Erdmann,Christian Hengstenberg,François Cambien,François Cambien,François Cambien,Alison H. Goodall,Alison H. Goodall,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Heribert Schunkert,John R. Thompson,Tim D. Spector,Christian Gieger,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Panos Deloukas,Panos Deloukas,Panos Deloukas,Nilesh J. Samani,Nilesh J. Samani +37 more
TL;DR: Increased BMI in adults of European origin is associated with increased methylation at the HIF3A locus in blood cells and in adipose tissue, and perturbation of hypoxia inducible transcription factor pathways could have an important role in the response to increased weight in people.
Journal ArticleDOI
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.
TL;DR: Theophylline induced a sixfold increase in HDAC activity in COPD AM lysates and significantly enhanced dexamethasone suppression of induced IL-8 release, an effect that was blocked by the HDAC inhibitor trichostatin A.
Journal ArticleDOI
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation.
Loukia Tsaprouni,Tsun-Po Yang,Jordana T. Bell,Katherine J. Dick,Stavroula Kanoni,James Nisbet,Ana Viñuela,Elin Grundberg,Christopher P. Nelson,Eshwar Meduri,Alfonso Buil,François Cambien,Christian Hengstenberg,Jeanette Erdmann,Heribert Schunkert,Alison H. Goodall,Willem H. Ouwehand,Emmanouil T. Dermitzakis,Tim D. Spector,Nilesh J. Samani,Panos Deloukas +20 more
TL;DR: The findings suggest the existence of dynamic, reversible site-specific methylation changes in response to cigarette smoking, which may contribute to the extended health risks associated with cigarette smoking.
Journal ArticleDOI
Metabolomic markers reveal novel pathways of ageing and early development in human populations
Cristina Menni,Gabriella Kastenmüller,Ann-Kristin Petersen,Jordana T. Bell,Maria Psatha,Pei-Chien Tsai,Christian Gieger,Holger Schulz,Idil Erte,Sally John,M. Julia Brosnan,Scott Wilson,Loukia Tsaprouni,Ee Mun Lim,Bronwyn G. A. Stuckey,Panos Deloukas,Robert P. Mohney,Karsten Suhre,Tim D. Spector,Ana M. Valdes +19 more
TL;DR: The data illustrate how metabolomic profiling linked with epigenetic studies can identify some key molecular mechanisms potentially determined in early development that produce long-term physiological changes influencing human health and ageing.