J
Jan F. C. Glatz
Researcher at Maastricht University
Publications - 309
Citations - 20133
Jan F. C. Glatz is an academic researcher from Maastricht University. The author has contributed to research in topics: Fatty acid & CD36. The author has an hindex of 72, co-authored 304 publications receiving 18662 citations. Previous affiliations of Jan F. C. Glatz include Maastricht University Medical Centre & Leiden University Medical Center.
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Journal ArticleDOI
2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes.
Dipanjan Chanda,Yvonne Oligschlaeger,Ilvy M. E. Geraets,Yilin Liu,Xiaoqing Zhu,Jieyi Li,Miranda Nabben,Will A. Coumans,Joost J. F. P. Luiken,Jan F. C. Glatz,Dietbert Neumann +10 more
TL;DR: Report reports that the endocannabinoid 2-arachidonoylglycerol (2-AG), via stimulation of cannabinoid type 1 (CB1) receptor and Ca2+/calmodulin-dependent protein kinase β, activates AMP-activated kinase (AMPK), leading to increased glucose uptake, and establishes that TNFα induces IR in cardiomyocytes.
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Modulation of glycogen metabolism of rat skeletal muscles by endurance training and testosterone treatment.
Eric van Breda,Hans A. Keizer,P. Geurten,Gerrit Van Kranenburg,Paul P.C.A. Menheere,Harm Kuipers,Jan F. C. Glatz +6 more
TL;DR: It is concluded that testosterone, at a pharmacological dose, potentiates the training-induced increase in glycogen content of skeletal muscle and induces a glycogen-sparing effect after submaximal exercise.
Journal ArticleDOI
Heart-type Fatty acid-binding protein in Acute Myocardial infarction Evaluation (FAME): Background and design of a diagnostic study in primary care
Madeleine H. E. Bruins Slot,Geert J. M. G. van der Heijden,Frans H. Rutten,Onno P. van der Spoel,E. Gijs Mast,Ad C. Bredero,Pieter A. Doevendans,Jan F. C. Glatz,Arno W. Hoes +8 more
TL;DR: This study is the first to assess the diagnostic value of H-FABP outside a hospital-setting, and it is unclear whether these results are equally promising when the test is used in primary care.
Journal ArticleDOI
Understanding the distinct subcellular trafficking of CD36 and GLUT4 during the development of myocardial insulin resistance
TL;DR: The proteins making up the trafficking machinery of CD36 need to be identified with special focus to the differences with the protein composition of the GLUT4 trafficking machinery, which may offer targets to rectify aberrant substrate uptake seen in the lipid-overloaded heart.
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Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart.
Lisa C. Heather,Mark A. Cole,Helen J. Atherton,Will A. Coumans,Rhys D. Evans,Damian J. Tyler,Jan F. C. Glatz,Joost J. F. P. Luiken,Kieran Clarke +8 more
TL;DR: The combined effects of T(3)-induced AMPK activation and insulin stimulation were associated with increased sarcolemmal GLUT4 localization and glycolytic flux in the hyperthyroid heart, associated with a sarcoLEmmal reorganization of fatty acid transporters.