J
Jan F. C. Glatz
Researcher at Maastricht University
Publications - 309
Citations - 20133
Jan F. C. Glatz is an academic researcher from Maastricht University. The author has contributed to research in topics: Fatty acid & CD36. The author has an hindex of 72, co-authored 304 publications receiving 18662 citations. Previous affiliations of Jan F. C. Glatz include Maastricht University Medical Centre & Leiden University Medical Center.
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Journal ArticleDOI
Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations.
Desiree Abdurrachim,Miranda Nabben,Verena Hoerr,Michael T. Kuhlmann,Philipp Bovenkamp,Philipp Bovenkamp,Jolita Ciapaite,Ilvy M. E. Geraets,Will A. Coumans,Joost J. F. P. Luiken,Jan F. C. Glatz,Michael Schaefers,Klaas Nicolay,Cornelius Faber,Cornelius Faber,Sven Hermann,Jeanine J. Prompers +16 more
TL;DR: The cardiac metabolic adaptations in diabetic mice seem to prevent the heart from failing upon pressure overload, suggesting that restoring the balance between glucose and fatty acid utilization is beneficial for cardiac function.
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Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.
Joost J. F. P. Luiken,Didier Vertommen,Susan L. Coort,Susan L. Coort,Daphna D. J. Habets,Mohammed El Hasnaoui,Maurice M.A.L. Pelsers,Benoit Viollet,Arend Bonen,Louis Hue,Mark H. Rider,Jan F. C. Glatz +11 more
TL;DR: The combined actions of PKD on cTnI phosphorylation and on GLUT4 translocation would efficiently link accelerated contraction mechanics to increased energy production when the heart is forced to increase its contractile activity.
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Recombinant human heart-type fatty acid-binding protein as standard in immunochemical assays.
Andrea Schreiber,Bernfried Specht,Maurice M.A.L. Pelsers,Jan F. C. Glatz,Torsten Börchers,Friedrich Spener +5 more
TL;DR: The recombinant human heart-type fatty acid-binding protein is now available as standard for immunoassays and is shown to show similar kinetic as well as equilibrium constants with respect to two monoclonal antibodies currently applied in immunochemical detection of heart- type fatty acidsbinding protein.
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Demonstration of Ischemia-Reperfusion Injury Separate From Postoperative Infarction in Coronary Artery Bypass Graft Patients
TL;DR: Perioperative myocardial injury can be diagnosed from the release of cardiac marker proteins into plasma already at 0.5 hours after the start of reperfusion, and fatty acid-binding protein is a more suitable plasma marker than are creatine kinase, creatine kinase-MB, or myoglobin.
Journal ArticleDOI
In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation
Graham P. Holloway,Laelie A. Snook,Robert J. Harris,Jan F. C. Glatz,Joost J. F. P. Luiken,Arend Bonen +5 more
TL;DR: Evidence is provided that in obese animals more fat accumulates within the heart as a result of their increased transport across the membranes of heart cells, not due to reductions in mitochondrial number or function.