J
Jan F. C. Glatz
Researcher at Maastricht University
Publications - 309
Citations - 20133
Jan F. C. Glatz is an academic researcher from Maastricht University. The author has contributed to research in topics: Fatty acid & CD36. The author has an hindex of 72, co-authored 304 publications receiving 18662 citations. Previous affiliations of Jan F. C. Glatz include Maastricht University Medical Centre & Leiden University Medical Center.
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Journal ArticleDOI
Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane.
Joost J. F. P. Luiken,David J. Dyck,Xiao-Xia Han,Narendra N. Tandon,Yoga Arumugam,Jan F. C. Glatz,Arend Bonen +6 more
TL;DR: It is shown for the first time that insulin can induce the translocation of FAT/CD36 from an intracellular depot to the plasma membrane, which reveals a previously unknown level of regulation of fatty acid transport by insulin and may well have important consequences in furthering the understanding of the relation between fatty acid metabolism and insulin resistance.
Journal ArticleDOI
Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein.
Frans A. van Nieuwenhoven,Appie H. Kleine,K. Will H. Wodzig,Wim Th. Hermens,Hans J. A. Kragten,Jos G. Maessen,Cees D. Punt,Marja P. Van Dieijen,Ger J. van der Vusse,Jan F. C. Glatz +9 more
TL;DR: The ratio of the concentrations of myoglobin over FABP in plasma from patients with muscle injury reflects the ratio found in the affected tissue, which allows the discrimination between myocardial and skeletal muscle injury in humans.
Journal ArticleDOI
Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification
D. M. Ouwens,Michaela Diamant,M. Fodor,Daphna D. J. Habets,Maurice M.A.L. Pelsers,M. El Hasnaoui,Z. C. Dang,C. E. van den Brom,R. Vlasblom,A. Rietdijk,Christa Boer,Susan L. Coort,Jan F. C. Glatz,Joost J. F. P. Luiken +13 more
TL;DR: The permanent presence of CD36 at the sarcolemma resulted in enhanced rates of LCFA uptake and myocardial triacylglycerol accumulation, and may contribute to the development of insulin resistance and diabetic cardiomyopathy.
Journal ArticleDOI
Modest PGC-1α Overexpression in Muscle in Vivo Is Sufficient to Increase Insulin Sensitivity and Palmitate Oxidation in Subsarcolemmal, Not Intermyofibrillar, Mitochondria
Carley R. Benton,James G. Nickerson,James Lally,Xiao-Xia Han,Graham P. Holloway,Jan F. C. Glatz,Joost J. F. P. Luiken,Terry E. Graham,John J. Heikkila,Arend Bonen +9 more
TL;DR: In skeletal muscle in vivo, a modest PGC-1α overexpression up-regulated selected plasmalemmal and mitochondrial fuel-handling proteins, increased SS (not IMF) mitochondrial fatty acid oxidation, and improved insulin sensitivity.
Journal ArticleDOI
Assessing Cardiac Metabolism
Heinrich Taegtmeyer,Martin E. Young,Gary D. Lopaschuk,E. Dale Abel,Henri Brunengraber,Victor M. Darley-Usmar,Christine Des Rosiers,Robert E. Gerszten,Jan F. C. Glatz,Julian L. Griffin,Robert J. Gropler,Hermann Georg Holzhuetter,Jorge R. Kizer,E. Douglas Lewandowski,Craig R. Malloy,Stefan Neubauer,Linda R. Peterson,Michael A. Portman,Fabio A. Recchia,Jennifer E. Van Eyk,Thomas J. Wang +20 more
TL;DR: The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism.