J
Jan F. C. Glatz
Researcher at Maastricht University
Publications - 309
Citations - 20133
Jan F. C. Glatz is an academic researcher from Maastricht University. The author has contributed to research in topics: Fatty acid & CD36. The author has an hindex of 72, co-authored 304 publications receiving 18662 citations. Previous affiliations of Jan F. C. Glatz include Maastricht University Medical Centre & Leiden University Medical Center.
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Journal ArticleDOI
Increased Fatty Acid-Binding Protein Concentration in Plasma of Patients with Chronic Renal Failure
TL;DR: To interpret properly the values of plasma FABP concentration, one has to take into account not only its source and rate of release into plasma but also its elimination from plasma, as any change in the clearance rate would affect its plasma concentration, and thus may lead to erroneous interpretation.
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Rat heart fatty acid-binding protein content is increased in experimental diabetes.
Jan F. C. Glatz,E. Vanbreda,H.A. Keizer,Y.F. Dejong,Jonathan R. T. Lakey,Ray V. Rajotte,A. Thompson,G.J. Vandervusse,Gary D. Lopaschuk +8 more
TL;DR: Data indicate that experimental diabetes induces a marked increase of the FABP content of rat heart and suggests that this protein is involved in the enhanced fatty acid utilization by the diabetic heart.
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Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus
Joep van der Leeuw,Joline W.J. Beulens,Susan van Dieren,Casper G. Schalkwijk,Jan F. C. Glatz,Marten H. Hofker,W M Monique Verschuren,Jolanda M. A. Boer,Yolanda van der Graaf,Frank L.J. Visseren,Linda M. Peelen,Yvonne T. van der Schouw +11 more
TL;DR: N‐terminal prohormone of B‐type natriuretic peptide, osteopontin, MMP‐3 were the only biomarkers significantly associated with an increased risk of CVE and improved predictive performance in both cohorts, but the number of patients reclassified to a different risk stratum was limited.
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Modeling of palmitate transport in the heart
TL;DR: The discovery that the dissociation occurs upon albumin binding to an endothelial surface receptor resolves the conundrum ofPalmitate transport across the luminal surface membrane and proves that there is a saturable sarcolemmal transporter or simply passive exchange.
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Regulation of sarcolemmal transport of substrates in the healthy and diseased heart.
TL;DR: Selective modulation of the sarcolemmal localization of fatty acid- and/or glucose transporters holds promise as a therapeutic tool to rectify a disruption of the cardiac substrate balance occurring in chronic cardiac disease.