J
Jan F. C. Glatz
Researcher at Maastricht University
Publications - 309
Citations - 20133
Jan F. C. Glatz is an academic researcher from Maastricht University. The author has contributed to research in topics: Fatty acid & CD36. The author has an hindex of 72, co-authored 304 publications receiving 18662 citations. Previous affiliations of Jan F. C. Glatz include Maastricht University Medical Centre & Leiden University Medical Center.
Papers
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Journal ArticleDOI
Increased intramyocellular lipids but unaltered in vivo mitochondrial oxidative phosphorylation in skeletal muscle of adipose triglyceride lipase-deficient mice
Patricia M. Nunes,T. van de Weijer,Andor Veltien,H.F.G. Arnts,Matthijs K. C. Hesselink,Jan F. C. Glatz,Patrick Schrauwen,Cees J. Tack,Arend Heerschap +8 more
TL;DR: Despite similar in vivo mitochondrial oxidative capacities, the electrostimulated muscles from ATGL(-/-) mice displayed significantly lower force production and increased muscle relaxation time than the WT.
Journal ArticleDOI
On-line flow displacement immunoassay for fatty acid-binding protein
Wilhelmina A Kaptein,Wilhelmina A Kaptein,Jakob Korf,Shong Cheng,Michael Yang,Jan F. C. Glatz,Reinhard Renneberg +6 more
TL;DR: The displacement system uses an inverse set-up: enzyme labelled monoclonal antibodies are associated to immobilized antigen, and are displaced by analyte in the sample, which permits detection of both physiological and pathological concentrations of fatty acid-binding protein in an on-line flow system.
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Immunohistochemical detection of very recent myocardial infarctions in humans with antibodies against heart-type fatty acid-binding protein.
Appie H. Kleine,Jan F. C. Glatz,Miek G. Havenith,Frans A. van Nieuwenhoven,Ger J. van der Vusse,FréT. Bosman +5 more
TL;DR: H-FABP immunostaining may detect very recent ischemia/ infarction in human myocardium and can be applied in routine autopsy pathology, strongly suggesting that immunohistochemical staining with antibodies to H- FABP can confirm the clinical diagnosis or suspicion of early myocardial infarctions.
Journal ArticleDOI
Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake
Yeliz Angin,Robert W. Schwenk,Reyhan Nergiz-Unal,Nicole Hoebers,Johan W. M. Heemskerk,Marijke J.E. Kuijpers,Will A. Coumans,Marc A. M. J. van Zandvoort,Arend Bonen,Dietbert Neumann,Jan F. C. Glatz,Joost J. F. P. Luiken +11 more
TL;DR: Ca(2+) signaling shows no involvement in AMPK-induced GLUT4/CD36 translocation and substrate uptake but elicits transporter translocation via a separate pathway requiring CaMKKβ/CaMKs.
Journal ArticleDOI
CD36 (SR-B2) as a Target to Treat Lipid Overload-Induced Cardiac Dysfunction
TL;DR: Insight into the subcellular trafficking machinery of CD36 will provide novel targets to treat the lipid-overloaded heart, and preliminary data suggest that these proteins may offer clues on how to manipulate myocardial lipid uptake, and thus could be promising targets for metabolic intervention therapy to Treat the failing heart.