Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide.
Laia Alemany,Maëlle Saunier,Isabel Alvarado-Cabrero,Beatriz Quirós,Jorge Salmerón,Hai-Rim Shin,Edyta C. Pirog,Núria Guimerà,Gustavo Hernández-Suárez,Ana Félix,Omar Clavero,Belen Lloveras,Elena Kasamatsu,Marc T. Goodman,Marc T. Goodman,Brenda Y. Hernandez,Jan Laco,Leopoldo Tinoco,D.T. Geraets,Charles F. Lynch,Václav Mandys,Mario Poljak,Robert Jach,Josep Verge,Christine Clavel,Cathy Ndiaye,Joellen Klaustermeier,Antonio L. Cubilla,Xavier Castellsagué,Ignacio G. Bravo,Michael Pawlita,William G. Quint,Nubia Muñoz,Francesc Bosch,Silvia de Sanjosé +34 more
TLDR
In view of the results of HPV DNA and high proportion of p16INK4a overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women.Abstract:
Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA25 system (version 1). A subset of 116 cancers was further tested for p16(INK4a) expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16(INK4a) overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16(INK4a) overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions.read more
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Carcinogenic human papillomavirus infection.
Mark Schiffman,John Doorbar,Nicolas Wentzensen,Silvia de Sanjosé,Carole Fakhry,Bradley J. Monk,Margaret Stanley,Silvia Franceschi +7 more
TL;DR: HPV testing will probably replace cytology-based cervical screening owing to greater reassurance when the test is negative, however, the effective implementation of HPV vaccination and screening globally remains a challenge.
Journal ArticleDOI
HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients
Xavier Castellsagué,Laia Alemany,Miquel Quer,Gordana Halec,Beatriz Quirós,Sara Tous,Omar Clavero,Llucia Alos,Thorsten Biegner,Tomasz Szafarowski,Maria Alejo,Dana Holzinger,Enrique Cadena,Edith Claros,Gillian Hall,Jan Laco,Mario Poljak,Maria Benevolo,Elena Kasamatsu,Hisham Mehanna,Cathy Ndiaye,Núria Guimerà,Belen Lloveras,Xavier León,Juan C. Ruiz-Cabezas,Isabel Alvarado-Cabrero,Chang Suk Kang,Jin-Kyoung Oh,Marcial Garcia-Rojo,Ermina Iljazovic,Oluseyi F. Ajayi,Flora Duarte,Ashrafun Nessa,Leopoldo Tinoco,Marco A. Duran-Padilla,Edyta C. Pirog,Halina Viarheichyk,Hesler Morales,Valérie Costes,Ana Félix,Maria Julieta V Germar,Marisa Mena,Arzu Ruacan,Asha Jain,Ravi Mehrotra,Marc T. Goodman,Luis Estuardo Lombardi,Annabelle Ferrera,Sani Malami,Estela I. Albanesi,Pablo Dabed,Carla Molina,Rubén López-Revilla,Václav Mandys,Manuel E. González,Julio Velasco,Ignacio G. Bravo,Wim Quint,Michael Pawlita,Nubia Muñoz,Silvia de Sanjosé,F. Xavier Bosch +61 more
TL;DR: This large international study to estimate fractions of head and neck cancers attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation confirms the important role ofHPVs in oropharyngeal cancer and drastically downplays the previously reported involvement of HPVs in the other HNCs.
Journal ArticleDOI
US assessment of HPV types in cancers: implications for current and 9-valent HPV vaccines.
Mona Saraiya,Elizabeth R. Unger,Trevor D. Thompson,Charles F. Lynch,Brenda Y. Hernandez,Christopher Lyu,Martin Steinau,Meg Watson,Edward J. Wilkinson,Claudia Hopenhayn,Glenn Copeland,Wendy Cozen,Edward S. Peters,Youjie Huang,Maria Sibug Saber,Sean F. Altekruse,Marc T. Goodman +16 more
TL;DR: In the United States, current vaccines will reduce most HPV-associated cancers; a smaller additional reduction would be contributed by the new 9-valent vaccine.
Journal ArticleDOI
Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience
Suzanne M. Garland,Susanne K. Kjaer,Nubia Muñoz,Stan L. Block,Darron R. Brown,Mark J. DiNubile,Brianna Lindsay,Barbara J. Kuter,Gonzalo Perez,Géraldine Dominiak-Felden,Alfred J. Saah,Rosybel Drury,Rituparna Das,Christine Velicer +13 more
TL;DR: Substantial reductions in HPV 6/11/16/18 infection, anogenital warts, and cervical lesions have been achieved.
Journal ArticleDOI
Epidemiology and burden of HPV-related disease.
TL;DR: The latest estimates of the global burden of HPV-related diseases, trends, the attributable fraction by HPV types, and the potential preventative fraction are summarized.
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Journal ArticleDOI
Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
Ruediger Klaes,Tibor Friedrich,Dimitry Spitkovsky,Ruediger Ridder,Wolfgang Rudy,Ulrich Petry,Gisela Dallenbach-Hellweg,Dietmar Schmidt,Magnus von Knebel Doeberitz +8 more
TL;DR: Data demonstrate that p16INK4a is a specific biomarker to identify dysplastic cervical epithelia in sections of cervical biopsy samples or cervical smears and that Dysplastic cells could also be identified in cervicalsmears using a specific p16ink4a monoclonal antibody.
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