J
Jean-Pierre Gorvel
Researcher at Aix-Marseille University
Publications - 239
Citations - 16211
Jean-Pierre Gorvel is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Brucella & Endosome. The author has an hindex of 67, co-authored 231 publications receiving 15005 citations. Previous affiliations of Jean-Pierre Gorvel include Centre national de la recherche scientifique & Aberystwyth University.
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Journal ArticleDOI
rab5 controls early endosome fusion in vitro.
TL;DR: In vitro findings strongly suggest that rab5 is involved in the process of early endosome fusion, and the inhibition mediated by anti-rab5 antibodies could be overcome by complementing the assay with the cytosol containing wild-type rab5, but not with the same cytOSol depleted of rab5.
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Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum.
Jean Celli,Chantal de Chastellier,Don-Marc Franchini,Javier Pizarro-Cerdá,Edgardo Moreno,Jean-Pierre Gorvel +5 more
TL;DR: It is shown in a model of Brucella abortus infection of murine bone marrow–derived macrophages that a fraction of the bacteria that survive an initial macrophage killing proceed to replicate in a compartment segregated from the endocytic pathway.
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Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
Javier Pizarro-Cerdá,Stepahane Meresse,Robert G. Parton,Gisou van der Goot,Alberto Sola-Landa,Ignacio López-Goñi,Edgardo Moreno,Jean-Pierre Gorvel +7 more
TL;DR: The results are compatible with the hypothesis that pathogenic B. abortus exploits the autophagic machinery of HeLa cells to establish an intracellular niche favorable for its replication within the ER.
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Hypervariable C-terminal domain of rab proteins acts as a targeting signal.
Philippe Chavrier,Jean-Pierre Gorvel,Ernst H. K. Stelzer,Kai Simons,Jean Gruenberg,Marino Zerial +5 more
TL;DR: Evidence is presented that the highly variable C-terminal domain contains structural elements necessary for the association of rab proteins with their specific target membranes in the endocytic pathway.
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Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway.
TL;DR: This study indicates that intracellular S. typhimurium occupies a unique niche, branching away from the traditional endocytic pathway between the early and late endosomal compartments.