Alex Rodriguez

TL;DR: The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene.

TL;DR: Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors.

TL;DR: Comparative analyses show a fascinating picture of conservation and divergence, revealing large blocks of gene orthology with rodents, scattered regions with more recent gene family expansions and deletions, and segments of coding and non-coding conservation with the distant fish species Takifugu.

TL;DR: The results of the largest examination of the quality of the finished DNA sequence are presented, based on a rigorous combination of laboratory experiments and computational analysis.

TL;DR: The 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its euchromatin, revealed 880 protein-coding genes, including metallothionein, cadherin and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukaemia.