R
Raphael Ho Tsong Fang
Researcher at Université Paris-Saclay
Publications - 12
Citations - 679
Raphael Ho Tsong Fang is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Viral load & Neutralizing antibody. The author has an hindex of 6, co-authored 12 publications receiving 301 citations. Previous affiliations of Raphael Ho Tsong Fang include Durham University & University of Paris-Sud.
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Journal ArticleDOI
Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
Pauline Maisonnasse,Jeremie Guedj,Vanessa Contreras,Sylvie Behillil,Sylvie Behillil,Caroline Solas,Romain Marlin,Thibaut Naninck,Andrés Pizzorno,Julien Lemaitre,Antonio Gonçalves,Nidhal Kahlaoui,Olivier Terrier,Raphael Ho Tsong Fang,Vincent Enouf,Vincent Enouf,Nathalie Dereuddre-Bosquet,Angela Brisebarre,Angela Brisebarre,Franck Touret,Catherine Chapon,Bruno Hoen,Bruno Lina,Manuel Rosa Calatrava,Sylvie van der Werf,Sylvie van der Werf,Xavier de Lamballerie,Roger Le Grand +27 more
TL;DR: Hydroxychloroquine did not confer protection against SARS-CoV-2 infection or reduce the viral load after infection in macaques; these findings do not support the use of hydroxy chloroquine as an antiviral drug treatment of COVID-19 in humans.
Journal ArticleDOI
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
Philip J. M. Brouwer,Mitch Brinkkemper,Pauline Maisonnasse,Nathalie Dereuddre-Bosquet,Marloes Grobben,Mathieu Claireaux,Marlon de Gast,Romain Marlin,Virginie Chesnais,Ségolène Diry,Joel D. Allen,Yasunori Watanabe,Yasunori Watanabe,Julia M. Giezen,Gius Kerster,Hannah L. Turner,Karlijn van der Straten,Cynthia A. van der Linden,Yoann Aldon,Thibaut Naninck,Ilja Bontjer,Judith A. Burger,Meliawati Poniman,Anna Z Mykytyn,Nisreen M.A. Okba,Edith E. Schermer,Mariëlle J. van Breemen,Rashmi Ravichandran,Tom G. Caniels,Jelle van Schooten,Nidhal Kahlaoui,Vanessa Contreras,Julien Lemaitre,Catherine Chapon,Raphael Ho Tsong Fang,Julien Villaudy,Kwinten Sliepen,Yme U. van der Velden,Bart L. Haagmans,Godelieve J. de Bree,Eric Ginoux,Andrew B. Ward,Max Crispin,Neil P. King,Sylvie van der Werf,Sylvie van der Werf,Marit J. van Gils,Roger Le Grand,Rogier W. Sanders +48 more
TL;DR: In this paper, a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein was proposed to curtail the severe acute respiratory syndrome coronavirus 2 pandemic.
Journal ArticleDOI
SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota.
Harry Sokol,Harry Sokol,Vanessa Contreras,Pauline Maisonnasse,Aurore Desmons,Benoit Delache,Valentin Sencio,Arnaud Machelart,Angela Brisebarre,Lydie Humbert,Lucie Deryuter,Emilie Gauliard,Séverine Heumel,Dominique Rainteau,Nathalie Dereuddre-Bosquet,Elisabeth Menu,Raphael Ho Tsong Fang,Antonin Lamaziere,Antonin Lamaziere,Loic Brot,Loic Brot,Celine Wahl,Cyriane Oeuvray,Nathalie Rolhion,Sylvie van der Werf,Stéphanie Ferreira,Roger Le Grand,François Trottein +27 more
TL;DR: Analysis of the effects of a SARS-CoV-2 infection in a nonhuman primate model suggests changes in the gut microbiota’s composition and functional activity during a severe acute respiratory syndrome coronavirus 2 infection might be instrumental in understanding and controling COVID 19.
Journal ArticleDOI
Two-Component Spike Nanoparticle Vaccine Protects Macaques from SARS-CoV-2 Infection
Philip J. M. Brouwer,Mitch Brinkkemper,Pauline Maisonasse,Nathalie Dereuddre-Bosquet,Marloes Grobben,Mathieu Claireaux,Marlon de Gast,Romain Marlin,Virginie Chesnais,Ségolène Diry,Joel D. Allen,Yasunori Watanabe,Julia M. Giezen,Gius Kerster,Hannah L. Turner,Karlijn van der Straten,Cynthia A. van der Linden,Yoann Aldon,Thibaut Naninck,Ilja Bontjer,Judith A. Burger,Meliawati Poniman,Anna Z Mykytyn,Nisreen M.A. Okba,Edith E. Schermer,Mariëlle J. van Breemen,Rashmi Ravichandran,Tom G. Caniels,Jelle van Schooten,Nidhal Kahlaoui,Vanessa Contreras,Julien Lemaitre,Catherine Chapon,Raphael Ho Tsong Fang,Julien Villaudy,Kwinten Sliepen,Yme U. van der Velden,Bart L. Haagmans,Godelieve J. de Bree,Eric Ginhoux,Andrew B. Ward,Max Crispin,Neil P. King,Sylvie van der Werf,Marit J. van Gils,Roger Le Grand,Rogier W. Sanders +46 more
TL;DR: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in mice, rabbits and cynomolgus macaques, resulting in strongly reduced viral infection and replication in upper and lower airways.
Journal ArticleDOI
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates.
Nerea Zabaleta,Wenlong Dai,U. Bhatt,Cécile Hérate,Pauline Maisonnasse,Jessica A. Chichester,Julio Sanmiguel,Reynette Estelien,Kristofer T. Michalson,Cheikh Talibouya Diop,Dawid Maciorowski,Nathalie Dereuddre-Bosquet,Mariangela Cavarelli,Anne-Sophie Gallouet,Thibaut Naninck,Nidhal Kahlaoui,Julien Lemaitre,Wenbin Qi,Elissa Hudspeth,Allison Cucalon,Cecilia Dyer,M. Betina Pampena,James J. Knox,Regina C. LaRocque,Richelle C. Charles,Dan Li,Maya Kim,Abigail Sheridan,Nadia Storm,Rebecca I. Johnson,Jared Feldman,Blake M. Hauser,Vanessa Contreras,Romain Marlin,Raphael Ho Tsong Fang,Catherine Chapon,Sylvie van der Werf,Sylvie van der Werf,Eric Zinn,Aisling Ryan,Dione T Kobayashi,Ruchi Chauhan,Marion McGlynn,Edward T. Ryan,Aaron G. Schmidt,Aaron G. Schmidt,Brian Price,Anna N. Honko,Anthony Griffiths,Sam Yaghmour,Robert Hodge,Michael R. Betts,Mason W. Freeman,James M. Wilson,Roger Le Grand,Luk H. Vandenberghe +55 more
TL;DR: In this article, the AAVCOVID-1, an adeno-associated viral (AAV), spike-gene-based vaccine candidate demonstrates potent immunogenicity in mouse and non-human primates following a single injection and confers complete protection from SARS-CoV-2 challenge in macaques.