J
Jérôme Ruel
Researcher at Aix-Marseille University
Publications - 37
Citations - 3286
Jérôme Ruel is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Hair cell & Spiral ganglion. The author has an hindex of 25, co-authored 35 publications receiving 2958 citations. Previous affiliations of Jérôme Ruel include Centre national de la recherche scientifique & University of Montpellier.
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Journal ArticleDOI
Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Thomas Papouin,Laurent Ladépêche,Laurent Ladépêche,Jérôme Ruel,Jérôme Ruel,Silvia Sacchi,Marilyne Labasque,Marwa Hanini,Laurent Groc,Laurent Groc,Loredano Pollegioni,Jean-Pierre Mothet,Stéphane H. R. Oliet,Stéphane H. R. Oliet +13 more
TL;DR: It is demonstrated that long-term potentiation and NMDA-induced neurotoxicity rely on synaptic NMDARs only, and long- term depression requires both synaptic and extrasynaptic receptors.
Journal ArticleDOI
Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss.
TL;DR: The high degree of protection observed with kynurenate attests that dendritic damage is an important component in noise-induced hearing loss and demonstrates that a synaptic repair mechanism occurring within the first few days post-exposure is partly responsible for the recovery of temporary threshold shifts after an acoustic trauma.
Journal ArticleDOI
Salicylate induces tinnitus through activation of cochlear NMDA receptors
TL;DR: Application of NMDA antagonists into the perilymphatic fluids of the cochlea blocked the increase in pole-jumping behavior induced by salicylate, suggesting that salicyllate induces tinnitus through activation of cochlear NMDA receptors.
Journal ArticleDOI
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.
Jérôme Ruel,Jérôme Ruel,S. Emery,Régis Nouvian,Tiphaine Bersot,Tiphaine Bersot,Bénédicte Amilhon,Jana M. Van Rybroek,Guy Rebillard,Guy Rebillard,Marc Lenoir,Marc Lenoir,Michel Eybalin,Michel Eybalin,Benjamin Delprat,Benjamin Delprat,Theru A. Sivakumaran,Bruno Giros,Salah El Mestikawy,Tobias Moser,Richard J.H. Smith,Marci M. Lesperance,Jean-Luc Puel,Jean-Luc Puel +23 more
TL;DR: It is concluded that deafness in Slc17a8-deficient mice is due to a specific defect of vesicular glutamate uptake and release and that VGLUT3 is essential for auditory coding at the IHC synapse.
Journal ArticleDOI
Physiology, pharmacology and plasticity at the inner hair cell synaptic complex.
Jérôme Ruel,Jing Wang,Jing Wang,Guy Rebillard,Guy Rebillard,Michel Eybalin,Michel Eybalin,Ruth Lloyd,Ruth Lloyd,Rémy Pujol,Rémy Pujol,Jean-Luc Puel,Jean-Luc Puel +12 more
TL;DR: The demonstration that NMDA receptors blockade delayed the re-growth of neurites suggests a neurotrophic role ofNMDA receptors in pathological conditions.