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Jian Wang

Researcher at Guangzhou Medical University

Publications -  1831
Citations -  76717

Jian Wang is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 94, co-authored 1018 publications receiving 57783 citations. Previous affiliations of Jian Wang include Northwestern University & Johns Hopkins University School of Medicine.

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Structural and functional definition of the pulmonary vein system in a chronic hypoxia-induced pulmonary hypertension rat model.

TL;DR: Investigation of the structural and functional changes in the PV isolated from the chronic hypoxia-induced PH rat model showed that CH caused an increase in right ventricular pressure, but did not affect the mean pulmonary venous pressure and the left atrial pressure, and fundamental data provided fundamental data to comprehensively define the PV system in CHPH rat model.
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PDGF/MEK/ERK axis represses Ca2+ clearance via decreasing the abundance of plasma membrane Ca2+ pump PMCA4 in pulmonary arterial smooth muscle cells.

TL;DR: The data proved the importance of the PDGF/MEK/ERK/PMCA4 axis in intracellular Ca2+ homeostasis in PASMCs, indicating a functional role of PMCA4 in pulmonary arterial remodeling and PAH development.
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A newborn patient with both annular pancreas and Meckel's diverticulum: A case report of an unusual association.

TL;DR: A rare case with both AP and Meckel's diverticulum, which was identified by abdominal exploration during diamond-shaped duodenoduodenostomy, demonstrates that abdominal exploration is essential for children with gastrointestinal malformations.
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Effective transport network driven by tortuosity gradient enables high-electrochem-active solid-state batteries

TL;DR: In this article , a tortuosity-gradient electrode architecture was proposed to promote fast charge transport, migrates the heterogeneous solid-state reaction, enhances electrochemical activity and extends cycle life in thick solid state electrodes.
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PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1α in colorectal cancer.

TL;DR: In this article, a novel therapeutic molecule (MPG-peptide) was used to inhibit HIF1α expression, which is necessary for its stabilization and oncogene function.