J
Jian Wang
Researcher at Guangzhou Medical University
Publications - 1831
Citations - 76717
Jian Wang is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 94, co-authored 1018 publications receiving 57783 citations. Previous affiliations of Jian Wang include Northwestern University & Johns Hopkins University School of Medicine.
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Hypoxia stimulates neural stem cell proliferation by increasing HIF‑1α expression and activating Wnt/β-catenin signaling
TL;DR: It is indicated that pathologic hypoxia stimulates NSC proliferation by increasing expression of HIF-1α and activating the Wnt/β-catenin signaling pathway, and the data suggest that Wnt or β-catanin signaling may play a key role in N SC proliferation under conditions of pathologic Hypoxia.
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Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer
Fan Mo,Dong Lin,Mandeep Takhar,Varune Rohan Ramnarine,Xin Dong,Robert H. Bell,Stanislav Volik,Kendric Wang,Hui Xue,Yuwei Wang,Anne Haegert,Shawn Anderson,Sonal Brahmbhatt,Nicholas Erho,Xinya Wang,Peter W. Gout,James Morris,R. Jeffrey Karnes,Robert B. Den,Eric A. Klein,Edward M. Schaeffer,Edward M. Schaeffer,Ashley E. Ross,Shancheng Ren,S. Cenk Sahinalp,S. Cenk Sahinalp,Yingrui Li,Xun Xu,Jun Wang,Jian Wang,Martin E. Gleave,Elai Davicioni,Yinghao Sun,Yuzhuo Wang,Colin Collins,Colin Collins +35 more
TL;DR: Profiling of stromal gene expression led to development of an SDMS that was validated as independently prognostic for the metastatic potential of prostate tumors and will strengthen decisions regarding selection of active surveillance versus surgery and/or radiation therapy for prostate cancer patients.
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The SH2-containing adapter protein GRB10 interacts with BCR-ABL
TL;DR: It is demonstrated that dimerization in yeast leads to autophosphorylation of tyrosine residues crucial for Bcr-Abl signaling in vivo, and the SH2-containing protein Grb10 is identified as a new binding partner for BCr-A Bl.
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Inflammatory responses after intracerebral hemorrhage: From cellular function to therapeutic targets
TL;DR: The search for effective immunotherapy to target specific cell type-mediated inflammation might represent a new direction for intracerebral hemorrhage treatment, separate from traditional anti-inflammatory drug discovery.
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Ca2+ Channels and Chronic Hypoxia
TL;DR: This review discusses data from the laboratory and others describing the effects of prolonged hypoxia on pulmonary vascular smooth muscle and endothelial cell Ca2+ homeostasis and the various Ca2+.