Jian Wang

TL;DR: The validation and application of a test based on Ion Proton technology for the rapid characterisation of single nucleotide variations, short insertions and deletions, copy number variations, and gene rearrangements in 145 genes with FFPE clinical specimens show concordance rate of 100% between results obtained by NGS and conventional test platforms.

TL;DR: In this paper, the authors reported on the generation of on-target gRNA activity data for 10,592 SpCas9 gRNAs and trained a deep learning model, CRISPRon, on 23,902 GRNAs.

TL;DR: It is found that ICH location influenced features of brain damage, microglia/macrophage activation, and behavioral deficits, and the 24-point neurologic deficit scoring system was most sensitive for evaluating locomotor abnormalities in all four models, especially on days 1, 3, and 7 post-ICH.

TL;DR: Changes in the expression of Src and angiogenic factors correlated with the progress of vascular permeability, especially early after reperfusion, suggesting that Src may represent a new therapeutic target for reducing tissue damage caused by increasedascular permeability.

TL;DR: A mutational landscape for pulmonary LELC is provided, showing a low burden of somatic mutations and high prevalence of copy number variations, and a road map to facilitate genome-guided personalized treatment is provided.