J
Jian Wang
Researcher at Guangzhou Medical University
Publications - 1831
Citations - 76717
Jian Wang is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 94, co-authored 1018 publications receiving 57783 citations. Previous affiliations of Jian Wang include Northwestern University & Johns Hopkins University School of Medicine.
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Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases.
Lin Lin,Yong Liu,Fengping Xu,Jinrong Huang,Tina Fuglsang Daugaard,Trine Skov Petersen,Bettina Hansen,Lingfei Ye,Qing Zhou,Fang Fang,Ling Yang,Shengting Li,Lasse Fløe,Kristopher Torp Jensen,Ellen Shrock,Fang Chen,Huanming Yang,Jian Wang,Xin Liu,Xun Xu,Lars Bolund,Anders Lade Nielsen,Yonglun Luo +22 more
TL;DR: It is proved that dCas9 methyltransferases cause efficient RNA-guided methylation of specific endogenous CpGs and can mediate transient inhibition of gene expression, which might be caused by d Cas9-mediated de novo DNA methylation as well as interference with transcription.
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Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan.
TL;DR: The findings showed that p53 gene mutation rate in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan is high and that the mutation types are different from those in UV-induced skin cancers.
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Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome
Xiaoming Liu,Xin Tong,Yuanqiang Zou,Xiaoqian Lin,Huiqin Zhao,Liu Tian,Zhuye Jie,Qi Wang,Zhenyu Zhang,Hao Rong Lu,Liang Xiao,Xu-jun Qiu,Jin Zi,Rong Wang,Xun Xu,Huanming Yang,Jian Wang,Yang Zong,Weibin Liu,Yong Hou,Shida Zhu,Huijue Jia,Tao Zhang +22 more
TL;DR: Wang et al. as discussed by the authors performed bidirectional Mendelian randomization analyses on 3,432 Chinese individuals with whole-genome, whole-metagenome, anthropometric and blood metabolic trait data.
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Perturbation of MicroRNA‐370/Lin‐28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma
Wen-Ping Xu,Min Yi,Qian-Qian Li,Weiping Zhou,Wen-Ming Cong,Yuan Yang,Bei-Fang Ning,Chuan Yin,Zhao-Wei Huang,Jian Wang,Hui Qian,Cai-Feng Jiang,Yue-Xiang Chen,Chun-Yan Xia,Hongyang Wang,Xin Zhang,Wei-Fen Xie +16 more
TL;DR: It is reported that miR‐370 was repressed in human hepatocellular carcinoma (HCC) tissues and hepatoma cell lines, and the involvement of a novel regulatory circuit consisting of miR-370, LIN28A, RelA/p65 and IL‐6 in HCC progression is demonstrated.
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Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice.
Zhen Zhang,Yuejia Song,Ze Zhang,Danyang Li,Hong Zhu,Rui Liang,Yunhe Gu,Yuxin Pang,Jiping Qi,He Wu,Jian Wang +10 more
TL;DR: It is concluded that HO-1 activation mediates early brain damage after ICH but promotes neurologic function recovery in the later stage of ICH.