J
Jian Wang
Researcher at Guangzhou Medical University
Publications - 1831
Citations - 76717
Jian Wang is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 94, co-authored 1018 publications receiving 57783 citations. Previous affiliations of Jian Wang include Northwestern University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Transcriptome and network changes in climbers at extreme altitudes
Fang Chen,Fang Chen,Wei Zhang,Wei Zhang,Yu Liang,Yu Liang,Jialiang Huang,Jialiang Huang,Kui Li,Kui Li,Christopher D. Green,Jiancheng Liu,Jiancheng Liu,Guojie Zhang,Bing Zhou,Bing Zhou,Xin Yi,Xin Yi,Wei Wang,Hang Liu,Xiaohong Xu,Feng Shen,Ning Qu,Yading Wang,Guoyi Gao,A. San,A. San,LuoSang JiangBai,Hua Sang,Xiangdong Fang,Karsten Kristiansen,Huanming Yang,Jun Wang,Jing-Dong J. Han,Jian Wang +34 more
TL;DR: It is predicted computationally and validated experimentally that increased OCT4 expression at extreme altitude can directly elevate the expression of hemoglobin genes, and established a new framework for analyzing the transcriptional regulatory network from a very limited number of samples.
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Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway.
Yuanyuan Li,Miki Ohira,Yong Zhou,Teng Xiong,Wen Luo,Chao Yang,Xiangchun Li,Zhibo Gao,Rui Zhou,Yohko Nakamura,Takehiko Kamijo,Yasuhiko Kaneko,Takeshi Taketani,Junichi Ueyama,Tatsuro Tajiri,Hongyan Zhang,Jian Wang,Huanming Yang,Ye Yin,and Akira Nakagawara +19 more
TL;DR: Genomic analyses demonstrated that primary and matched recurrent or metastatic tumors obtained from sporadic and monozygotic twin NBs were clonally related with variable extents of genetic heterogeneity.
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KRT15 overexpression predicts poor prognosis in colorectal cancer
TL;DR: Qualitative real-time polymerase chain reaction results indicate KRT15 is highly expressed in colorectal cancer and may serve as a prognostic biomarker.
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rTMS Ameliorates PTSD Symptoms in Rats by Enhancing Glutamate Transmission and Synaptic Plasticity in the ACC via the PTEN/Akt Signalling Pathway.
Gao-hua Liu,Dayun Feng,Jian Wang,Haifeng Zhang,Zhengwu Peng,Min Cai,Jing Yang,Rui-Guo Zhang,Huaning Wang,Shengxi Wu,Qingrong Tan +10 more
TL;DR: This study provides convincing evidence for the effectiveness of rTMS treatment on PTSD and suggests that its potential mechanism involves remodelling neuronal synaptic plasticity via the PTEN/Akt signalling pathway.
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Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells.
Jian Wang,Xiaoye Lv,Xiutian Guo,Yanbo Dong,Peipei Peng,Fang Huang,Peng Wang,Haoqian Zhang,Jianguang Zhou,Youliang Wang,Bo Wei,Zeng Fu Shang,Shanhu Li +12 more
TL;DR: The PI3K/AKT/mTOR pathway is constitutively active in PTEN-deficient cancer cells, and its targeted inhibition has significant anti-tumor effects.