J
Jian Wang
Researcher at Guangzhou Medical University
Publications - 1831
Citations - 76717
Jian Wang is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 94, co-authored 1018 publications receiving 57783 citations. Previous affiliations of Jian Wang include Northwestern University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Clinical Characteristics of Patients Infected With the Novel 2019 Coronavirus (SARS-Cov-2) in Guangzhou, China.
Yaping Wang,Baolin Liao,Yan Guo,Feng Li,Chunliang Lei,Fuchun Zhang,Weiping Cai,Wenxin Hong,Yu Zeng,Shuang Qiu,Jian Wang,Yueping Li,Xilong Deng,Jianping Li,Guangming Xiao,Fengxia Guo,Xunxi Lai,Zhiwei Liang,Xueliang Wen,Pinghong Li,Qian Jiao,Fangfei Xiang,Yong Wang,Chenghui Ma,Zhiwei Xie,Weiyin Lin,Yanrong Wu,Xiaoping Tang,Linghua Li,Yujuan Guan +29 more
TL;DR: Most of the patients infected with SARS-CoV-2 in Guangzhou, China are not severe cases and patients with older age, male, and decreased albumin level were more likely to develop into severe ones.
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Mutations in topoisomerase IIβ result in a B cell immunodeficiency
Lori Broderick,Lori Broderick,Shawn Yost,Shawn Yost,Dong Li,Matthew D. McGeough,Laela M. Booshehri,Marisela Guaderrama,Susannah Brydges,Karolina Kucharova,Niraj C. Patel,Margaret H. Harr,Margaret H. Harr,Hakon Hakonarson,Hakon Hakonarson,Elaine H. Zackai,Elaine H. Zackai,Ian G. Cowell,Caroline A. Austin,Boris Hügle,Corinna Gebauer,Jian-Guo Zhang,Xun Xu,Jian Wang,Ben A. Croker,Kelly A. Frazer,Kelly A. Frazer,Christopher D. Putnam,Christopher D. Putnam,Hal M. Hoffman,Hal M. Hoffman +30 more
TL;DR: It is demonstrated that patient mutations in TOP2B have a dominant negative effect on enzyme function, resulting in defective proliferation, survival of B-2 cells, causing a block in B cell development, and impair humoral function in response to immunization.
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Study on Enhancement Principle and Stabilization for the Luminol-H2O2-HRP Chemiluminescence System.
Lihua Yang,Maojun Jin,Pengfei Du,Ge Chen,Chan Zhang,Jian Wang,Fen Jin,Hua Shao,Yongxin She,Shanshan Wang,Zheng Lufei,Jing Wang +11 more
TL;DR: It is found that pH value, ionic strength, 4-IMP, 5-IOP, 3-BOP, HIOP, H2O2 and luminol have little influence on luminescent stabilization, while HRP has a great influence.
Journal ArticleDOI
Slow resolution of inflammation in severe adult dengue patients
Lingzhai Zhao,Xiuyan Huang,Wenxin Hong,Shuang Qiu,Jian Wang,Lei Yu,Yaoying Zeng,Xinghua Tan,Fuchun Zhang +8 more
TL;DR: The results revealed the coexistence of excessive inflammatory response and slow resolution of inflammation in severe adult dengue patients, suggesting suppression and/or pro-resolution of inflammation could be a potential therapeutic approach for treatment of severe d Dengue.
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Deep whole-genome sequencing of 90 Han Chinese genomes.
Tianming Lan,Haoxiang Lin,Wenjuan Zhu,Tellier Christian Asker Melchior Laurent,Mengcheng Yang,Xin Liu,Jun Wang,Jian Wang,Huanming Yang,Xun Xu,Xiaosen Guo +10 more
TL;DR: This work has performed whole-genome sequencing at a high depth of 90 unrelated individuals of Chinese ancestry, collected from the 1000 Genomes Project samples, and built a greatly expanded spectrum of genetic variation for the Han Chinese genome.