J
Joanne Lim
Researcher at United States Department of Energy
Publications - 9
Citations - 2001
Joanne Lim is an academic researcher from United States Department of Energy. The author has contributed to research in topics: Chromatin & Transcription factor. The author has an hindex of 6, co-authored 6 publications receiving 1720 citations. Previous affiliations of Joanne Lim include Joint Genome Institute & Genome Institute of Singapore.
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Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.
Guoliang Li,Xiaoan Ruan,Raymond K. Auerbach,Kuljeet Singh Sandhu,Meizhen Zheng,Ping Wang,Huay Mei Poh,Yufen Goh,Joanne Lim,Jingyao Zhang,Hui Shan Sim,Su Qin Peh,Fabianus Hendriyan Mulawadi,Chin Thing Ong,Yuriy L. Orlov,Shuzhen Hong,Zhizhuo Zhang,Steve Landt,Debasish Raha,Ghia Euskirchen,Chia-Lin Wei,Weihong Ge,Huaien Wang,Carrie A. Davis,Katherine I. Fisher-Aylor,Ali Mortazavi,Mark Gerstein,Thomas R. Gingeras,Barbara J. Wold,Yi Sun,Melissa J. Fullwood,Edwin Cheung,Edwin Cheung,Edison T. Liu,Wing-Kin Sung,Wing-Kin Sung,Michael Snyder,Yijun Ruan,Yijun Ruan +38 more
TL;DR: In conclusion, this study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells through widespread promoter-centered intragenic, extragenics, and intergenic interactions.
Journal ArticleDOI
Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations
Yubo Zhang,Chee Hong Wong,Ramon Y. Birnbaum,Guoliang Li,Rebecca Favaro,Chew Yee Ngan,Joanne Lim,Eunice Tai,Huay Mei Poh,Eleanor Wong,Fabianus Hendriyan Mulawadi,Wing-Kin Sung,Silvia K. Nicolis,Nadav Ahituv,Yijun Ruan,Chia-Lin Wei,Chia-Lin Wei +16 more
TL;DR: This study explores the transcriptional interactomes of three mouse cells of progressive lineage commitment and sets the stage for the full-scale dissection of spatial and temporal genome structures and their roles in orchestrating development.
Journal ArticleDOI
Large-Scale Functional Organization of Long-Range Chromatin Interaction Networks
Kuljeet Singh Sandhu,Guoliang Li,Huay Mei Poh,Yu Ling Kelly Quek,Yu Ling Kelly Quek,Yee Yen Sia,Su Qin Peh,Fabianus Hendriyan Mulawadi,Joanne Lim,Mile Šikić,Francesca Menghi,Anbupalam Thalamuthu,Wing-Kin Sung,Wing-Kin Sung,Xiaoan Ruan,Melissa J. Fullwood,Melissa J. Fullwood,Edison T. Liu,Peter Csermely,Yijun Ruan +19 more
TL;DR: A systems-level evolutionary framework is revealed that shapes functionally compartmentalized and error-tolerant transcriptional regulation of human genome in three dimensions.
Journal ArticleDOI
Lineage-specific chromatin signatures reveal a regulator of lipid metabolism in microalgae.
Chew Yee Ngan,Chee Hong Wong,Cindy Choi,Yuko Yoshinaga,Katherine B. Louie,Katherine B. Louie,Jing Jia,Cindy Chen,Benjamin P. Bowen,Benjamin P. Bowen,Haoyu Cheng,Lauriebeth Leonelli,Rita Kuo,Richard Baran,José G. García-Cerdán,Abhishek Pratap,Abhishek Pratap,Mei Wang,Joanne Lim,Hope Tice,Chris Daum,Jian Xu,Trent R. Northen,Trent R. Northen,Axel Visel,Axel Visel,Axel Visel,James Bristow,Krishna K. Niyogi,Krishna K. Niyogi,Chia-Lin Wei +30 more
TL;DR: The comprehensive maps of functional chromatin signatures in a major clade of eukaryotic life and the discovery of a transcriptional regulator of algal lipid metabolism will facilitate targeted engineering strategies to mediate high lipid production in microalgae.
Journal ArticleDOI
Impact of library preparation protocols and template quantity on the metagenomic reconstruction of a mock microbial community.
Robert M. Bowers,Alicia Clum,Hope Tice,Joanne Lim,Kanwar Singh,Doina Ciobanu,Chew Yee Ngan,Jan Fang Cheng,Susannah G. Tringe,Tanja Woyke +9 more
TL;DR: This benchmark study provides recommendations for library creation of representative and minimally biased metagenome shotgun sequencing, enabling insights into functional attributes of low biomass ecosystem microbial communities.