H
Huay Mei Poh
Researcher at Genome Institute of Singapore
Publications - 14
Citations - 2206
Huay Mei Poh is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Chromatin & ChIA-PET. The author has an hindex of 10, co-authored 13 publications receiving 1905 citations. Previous affiliations of Huay Mei Poh include Agency for Science, Technology and Research.
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Journal ArticleDOI
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.
Guoliang Li,Xiaoan Ruan,Raymond K. Auerbach,Kuljeet Singh Sandhu,Meizhen Zheng,Ping Wang,Huay Mei Poh,Yufen Goh,Joanne Lim,Jingyao Zhang,Hui Shan Sim,Su Qin Peh,Fabianus Hendriyan Mulawadi,Chin Thing Ong,Yuriy L. Orlov,Shuzhen Hong,Zhizhuo Zhang,Steve Landt,Debasish Raha,Ghia Euskirchen,Chia-Lin Wei,Weihong Ge,Huaien Wang,Carrie A. Davis,Katherine I. Fisher-Aylor,Ali Mortazavi,Mark Gerstein,Thomas R. Gingeras,Barbara J. Wold,Yi Sun,Melissa J. Fullwood,Edwin Cheung,Edwin Cheung,Edison T. Liu,Wing-Kin Sung,Wing-Kin Sung,Michael Snyder,Yijun Ruan,Yijun Ruan +38 more
TL;DR: In conclusion, this study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells through widespread promoter-centered intragenic, extragenics, and intergenic interactions.
Journal ArticleDOI
Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations
Yubo Zhang,Chee Hong Wong,Ramon Y. Birnbaum,Guoliang Li,Rebecca Favaro,Chew Yee Ngan,Joanne Lim,Eunice Tai,Huay Mei Poh,Eleanor Wong,Fabianus Hendriyan Mulawadi,Wing-Kin Sung,Silvia K. Nicolis,Nadav Ahituv,Yijun Ruan,Chia-Lin Wei,Chia-Lin Wei +16 more
TL;DR: This study explores the transcriptional interactomes of three mouse cells of progressive lineage commitment and sets the stage for the full-scale dissection of spatial and temporal genome structures and their roles in orchestrating development.
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Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
Rahul Nahar,Weiwei Zhai,Weiwei Zhai,Tong Zhang,Angela Takano,Alexis Jiaying Khng,Yin Yeng Lee,Xingliang Liu,Chong Hee Lim,Tina P.T. Koh,Zaw Win Aung,Tony Kiat Hon Lim,Lavanya Veeravalli,Ju Yuan,Audrey S.M. Teo,Cheryl Xueli Chan,Huay Mei Poh,Ivan M. L. Chua,Audrey Ann Liew,Dawn Pingxi Lau,Xue Lin Kwang,Chee Keong Toh,Wan-Teck Lim,Bing Lim,Wai Leong Tam,Eng Huat Tan,Axel M. Hillmer,Daniel Shao-Weng Tan +27 more
TL;DR: It is shown that these EGFR mutant lung adenocarcinoma LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance.
Journal ArticleDOI
Large-Scale Functional Organization of Long-Range Chromatin Interaction Networks
Kuljeet Singh Sandhu,Guoliang Li,Huay Mei Poh,Yu Ling Kelly Quek,Yu Ling Kelly Quek,Yee Yen Sia,Su Qin Peh,Fabianus Hendriyan Mulawadi,Joanne Lim,Mile Šikić,Francesca Menghi,Anbupalam Thalamuthu,Wing-Kin Sung,Wing-Kin Sung,Xiaoan Ruan,Melissa J. Fullwood,Melissa J. Fullwood,Edison T. Liu,Peter Csermely,Yijun Ruan +19 more
TL;DR: A systems-level evolutionary framework is revealed that shapes functionally compartmentalized and error-tolerant transcriptional regulation of human genome in three dimensions.
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Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity
Fei Yao,Fei Yao,Jaya P. Kausalya,Yee Yen Sia,Yee Yen Sia,Audrey S. M. Teo,Audrey S. M. Teo,Wah Heng Lee,Alicia G.M. Ong,Zhenshui Zhang,Joanna H.J. Tan,Guoliang Li,Denis Bertrand,Xingliang Liu,Huay Mei Poh,Peiyong Guan,Peiyong Guan,Feng Zhu,Thushangi Nadeera Pathiraja,Thushangi Nadeera Pathiraja,Pramila N. Ariyaratne,Jaideepraj Rao,Xing Yi Woo,Shaojiang Cai,Fabianus Hendriyan Mulawadi,Wan Ting Poh,Lavanya Veeravalli,Chee Seng Chan,Seong Soo Lim,See Ting Leong,Say Chuan Neo,Poh Sum D Choi,Elaine G.Y. Chew,Niranjan Nagarajan,Pierre-Étienne Jacques,Jimmy Bok Yan So,Jimmy Bok Yan So,Xiaoan Ruan,Khay Guan Yeoh,Khay Guan Yeoh,Patrick Tan,Wing-Kin Sung,Wing-Kin Sung,Walter Hunziker,Walter Hunziker,Yijun Ruan,Axel M. Hillmer,Axel M. Hillmer +47 more
TL;DR: Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, 15 gastric cancers from Southeast Asians were analyzed and recurrent fusions between CLDN18, a tight junction gene, and ARHGAP26, a gene encoding a RHOA inhibitor were found.