Joel A G van Roon

TL;DR: High-dimensional single-cell protein and RNA expression data is integrated to identify distinct markers to delineate monocytes from conventional DC2 (cDC2s), further unravel the heterogeneity of DC subpopulations in health and disease and may pave the way for the identification of specific DC subset-targeting therapies.

TL;DR: The findings suggest that the interaction of CD4+,CD25+ Treg cells with activated monocytes in the joint might lead to diminished suppressive activity of CD 4+,CD 25+ T Reg cells in vivo, thus contributing to the chronic inflammation in RA.

TL;DR: The important role of T helper cells, macrophages, dendritic cells (DC), and B cells in local tissue destruction in RA has been described extensively and several antiinflammatory mechanisms in response to the proinflammatory activity are activated in the RA joint in an attempt to control the dysregulated (auto)immune reactivity.

TL;DR: Patients with GCs are characterized by more severe disease, although the small number of studies and their design hamper generalizability of results, and the strongly increased risk of lymphoma development warrant intensive studies for the role of germinal centers in the immunopathology of pSS.

TL;DR: This multi-biomarker test performed well in the assessment of disease activity in RA patients in the CAMERA study and could be used to complement currently available disease activity measures and improve patient care and outcomes.