S
Sergio Erdal Irac
Researcher at National University of Singapore
Publications - 10
Citations - 1549
Sergio Erdal Irac is an academic researcher from National University of Singapore. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 6, co-authored 9 publications receiving 1023 citations. Previous affiliations of Sergio Erdal Irac include Singapore Immunology Network & Agency for Science, Technology and Research.
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Journal ArticleDOI
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams,Martin Guilliams,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Charlotte L. Scott,Naomi McGovern,Dorine Sichien,Svetoslav Chakarov,Sofie Van Gassen,Jinmiao Chen,Michael Poidinger,Sofie De Prijck,Simon Tavernier,Ivy Low,Sergio Erdal Irac,Citra Nurfarah Zaini Mattar,Hermi Sumatoh,Gillian Low,Tam John Kit Chung,Dedrick Kok Hong Chan,Ker-Kan Tan,Tony Lim Kiat Hon,Even Fossum,Bjarne Bogen,Mahesh Choolani,Jerry Kok Yen Chan,Anis Larbi,Hervé Luche,Sandrine Henri,Yvan Saeys,Evan W. Newell,Bart N. Lambrecht,Bart N. Lambrecht,Bernard Malissen,Florent Ginhoux +34 more
TL;DR: A universal toolbox for the automated identification of DCs through unsupervised analysis of conventional flow cytometry and mass cytometry data obtained from multiple mouse, macaque, and human tissues is provided and validated.
Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
Journal ArticleDOI
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Charles-Antoine Dutertre,Charles-Antoine Dutertre,Etienne Becht,Sergio Erdal Irac,Sergio Erdal Irac,Ahad Khalilnezhad,Ahad Khalilnezhad,Vipin Narang,Shabnam Khalilnezhad,Pei Y. Ng,Lucas L van den Hoogen,Jing Yao Leong,Bernett Lee,Marion Chevrier,Xiao Meng Zhang,Pearly Yong,Geraldine Koh,Josephine Lum,Shanshan W. Howland,Esther Wing Hei Mok,Jinmiao Chen,Anis Larbi,Henry K.K. Tan,Tony Kiat Hon Lim,Panagiota Karagianni,Athanasios G. Tzioufas,Benoit Malleret,Benoit Malleret,Joshua Brody,Salvatore Albani,Joel A G van Roon,Timothy R D J Radstake,Evan W. Newell,Florent Ginhoux,Florent Ginhoux +34 more
TL;DR: High-dimensional single-cell protein and RNA expression data is integrated to identify distinct markers to delineate monocytes from conventional DC2 (cDC2s), further unravel the heterogeneity of DC subpopulations in health and disease and may pave the way for the identification of specific DC subset-targeting therapies.
Journal ArticleDOI
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease.
Kevin Mulder,Kevin Mulder,Kevin Mulder,Amit Ashok Patel,Amit Ashok Patel,Wan Ting Kong,Cécile Piot,Evelyn Halitzki,Evelyn Halitzki,Garett Dunsmore,Garett Dunsmore,Shabnam Khalilnezhad,Sergio Erdal Irac,Agathe Dubuisson,Agathe Dubuisson,Marion Chevrier,Xiao Meng Zhang,John Kit Chung Tam,Tony Kiat Hon Lim,Regina Men Men Wong,Rhea Pai,Ahmed Ibrahim Samir Khalil,Pierce K. H. Chow,Suny Z. Wu,Suny Z. Wu,Ghamdan Al-Eryani,Ghamdan Al-Eryani,Daniel L. Roden,Daniel L. Roden,Alexander Swarbrick,Alexander Swarbrick,Jerry Kok Yen Chan,Salvatore Albani,Lisa Derosa,Laurence Zitvogel,Ankur Sharma,Ankur Sharma,Ankur Sharma,Jinmiao Chen,Aymeric Silvin,Aymeric Silvin,Antonio Bertoletti,Camille Blériot,Camille Blériot,Charles-Antoine Dutertre,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux +47 more
TL;DR: The authors integrated 178,651 mononuclear phagocytes (MNPs) from 13 tissues across 41 datasets to generate a MNP single-cell RNA compendium (MNP-VERSE), a publicly available tool to map MNPs and define conserved gene signatures of MNP populations.
Journal ArticleDOI
Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy
Alfonso Tan-Garcia,Fritz Lai,Joe Poh Sheng Yeong,Sergio Erdal Irac,Pei Y. Ng,Rasha Msallam,Jeffrey Chun Tatt Lim,Lu-En Wai,Christine Y.L. Tham,Su P. Choo,Tony Kiat Hon Lim,Dan Y. Young,Roberta D'Ambrosio,Elisabetta Degasperi,Riccardo Perbellini,Evan W. Newell,Nina Le Bert,Florent Ginhoux,Antonio Bertoletti,Antonio Bertoletti,Qingfeng Chen,Qingfeng Chen,Charles-Antoine Dutertre,Charles-Antoine Dutertre +23 more
TL;DR: It is shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) plays an important role in the development of liver fibrosis and support the use of anti-GM- CSF neutralising antibodies for the management of patients with chronic liver disease resulting from both viral and non-viral causes.