J
Johan Staaf
Researcher at Lund University
Publications - 179
Citations - 10039
Johan Staaf is an academic researcher from Lund University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 46, co-authored 153 publications receiving 8416 citations. Previous affiliations of Johan Staaf include University College Cork.
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Journal ArticleDOI
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Serena Nik-Zainal,Serena Nik-Zainal,Helen Davies,Johan Staaf,Manasa Ramakrishna,Dominik Glodzik,Xueqing Zou,Inigo Martincorena,Ludmil B. Alexandrov,Sancha Martin,David C. Wedge,Peter Van Loo,Young Seok Ju,Michiel M. Smid,Arie B. Brinkman,Sandro Morganella,Miriam Ragle Aure,Ole Christian Lingjærde,Anita Langerød,Markus Ringnér,Sung-Min Ahn,Sandrine Boyault,Jane E. Brock,Annegien Broeks,Adam Butler,Christine Desmedt,Luc Dirix,Serge Dronov,Aquila Fatima,John A. Foekens,Moritz Gerstung,Gerrit Gk Hooijer,Se Jin Jang,David Jones,Hyung-Yong Kim,Tari Ta King,Savitri Krishnamurthy,Hee Jin Lee,Jeong-Yeon Lee,Yang Li,Stuart McLaren,Andrew Menzies,Ville Mustonen,Sarah O’Meara,Iris Pauporté,Xavier Pivot,Colin Ca Purdie,Keiran Raine,Kamna Ramakrishnan,Germán Fg Rodríguez-González,Gilles Romieu,Anieta M. Sieuwerts,Peter Pt Simpson,Rebecca Shepherd,Lucy Stebbings,Olafur Oa Stefansson,Jon W. Teague,Stefania Tommasi,Isabelle Treilleux,Gert Van den Eynden,Peter B. Vermeulen,Anne Vincent-Salomon,Lucy R. Yates,Carlos Caldas,Laura Van't Veer,Andrew Tutt,Andrew Tutt,Stian Knappskog,Benita Kiat Tee Bk Tan,Jos Jonkers,Åke Borg,Naoto T. Ueno,Christos Sotiriou,Alain Viari,P. Andrew Futreal,Peter J. Campbell,Paul N. Span,Steven Van Laere,Sunil R. Lakhani,Jorunn E. Eyfjord,Alastair M Thompson,Ewan Birney,Hendrik G. Stunnenberg,Marc J. van de Vijver,John W.M. Martens,Anne Lise Børresen-Dale,Andrea L. Richardson,Gu Kong,Gilles Thomas,Michael R. Stratton +89 more
TL;DR: This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
Journal ArticleDOI
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
Helen Davies,Dominik Glodzik,Sandro Morganella,Lucy R. Yates,Johan Staaf,Xueqing Zou,Manasa Ramakrishna,Manasa Ramakrishna,Sancha Martin,Sandrine Boyault,Anieta M. Sieuwerts,Peter T. Simpson,Tari A Ta King,Keiran Raine,Jorunn E. Eyfjord,Gu Kong,Åke Borg,Ewan Birney,Hendrik G. Stunnenberg,Marc J. van de Vijver,Anne Lise Børresen-Dale,John W.M. Martens,Paul N. Span,Sunil R. Lakhani,Sunil R. Lakhani,Anne Vincent-Salomon,Christos Sotiriou,Andrew Tutt,Alastair M Thompson,Steven Van Laere,Andrea L. Richardson,Alain Viari,Peter J. Campbell,Michael R. Stratton,Serena Nik-Zainal +34 more
TL;DR: In this article, a weighted model called HRDetect was developed to accurately detect BRCA1/BRCA2-deficient samples with 98.7% sensitivity (area under the curve (AUC) = 0.98).
Journal ArticleDOI
GOBO: Gene Expression-Based Outcome for Breast Cancer Online.
TL;DR: A multifunctional user-friendly online tool, GOBO is described, allowing a range of different analyses to be performed in an 1881-sample breast tumor data set, and a 51- sample breast cancer cell line set, both generated on Affymetrix U133A microarrays.
Journal ArticleDOI
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
Lao H. Saal,Sofia K. Gruvberger-Saal,Camilla Persson,Kristina Lövgren,Mervi Jumppanen,Johan Staaf,Göran Jönsson,Maira M. Pires,Matthew Maurer,Karolina Holm,Susan Koujak,Shivakumar Subramaniyam,Johan Vallon-Christersson,Håkan Olsson,Tao Su,Lorenzo Memeo,Thomas Ludwig,Stephen P. Ethier,Morten Krogh,Matthias Szabolcs,Vundavalli V. Murty,Jorma Isola,Hanina Hibshoosh,Ramon Parsons,Åke Borg +24 more
TL;DR: It is shown that heterozygous inactivation of the tumor suppressor gene Pten leads to the formation of basal-like mammary tumors in mice, and that loss of PTEN expression is significantly associated with the BBC subtype in human sporadic and BRCA1-associated hereditary breast cancers.
Journal ArticleDOI
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Karolina Holm,Cecilia Hegardt,Johan Staaf,Johan Vallon-Christersson,Göran Jönsson,Håkan Olsson,Åke Borg,Markus Ringnér +7 more
TL;DR: It is found that breast cancers of the basal-like, luminal A and luminal B molecular subtypes harbour specific methylation profiles, suggesting that methylation may play an important role in the development of breast cancers.