J
John D. Gillece
Researcher at Translational Genomics Research Institute
Publications - 47
Citations - 2877
John D. Gillece is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Population & Multilocus sequence typing. The author has an hindex of 23, co-authored 41 publications receiving 2257 citations.
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Journal ArticleDOI
Staphylococcus aureus CC398: Host Adaptation and Emergence of Methicillin Resistance in Livestock
Lance B. Price,Marc Stegger,Henrik Hasman,Maliha Aziz,Jesper Larsen,Paal Skytt Andersen,Talima Pearson,Andrew E. Waters,Jeffrey T. Foster,James M. Schupp,John D. Gillece,Elizabeth M. Driebe,Cindy M. Liu,Cindy M. Liu,Burkhard Springer,Irena Zdovc,Antonio Battisti,Alessia Franco,Jacek Żmudzki,Stefan Schwarz,Patrick Butaye,Eric Jouy,Constança Pomba,M. Concepción Porrero,Raymond Ruimy,Tara C. Smith,D. Ashley Robinson,J. Scott Weese,Carmen Sofia Arriola,Fangyou Yu,Frédéric Laurent,Paul Keim,Paul Keim,Robert Skov,Frank Møller Aarestrup +34 more
TL;DR: The results strongly suggest that livestock-associated MRSA CC398 originated in humans as MSSA, which appears to have undergone a rapid radiation in conjunction with the jump from humans to livestock, where it subsequently acquired tetracycline and methicillin resistance.
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Population Genetics of Vibrio cholerae from Nepal in 2010: Evidence on the Origin of the Haitian Outbreak
Rene S. Hendriksen,Lance B. Price,James M. Schupp,John D. Gillece,Rolf Sommer Kaas,David M. Engelthaler,Valeria Bortolaia,Talima Pearson,Andrew E. Waters,Bishnu Prasad Upadhyay,Sirjana Devi Shrestha,Shailaja Adhikari,Geeta Shakya,Paul Keim,Paul Keim,Frank Møller Aarestrup +15 more
TL;DR: Results in this study are consistent with Nepal as the origin of the Haitian outbreak, highlighting how rapidly infectious diseases might be transmitted globally through international travel and how public health officials need advanced molecular tools along with standard epidemiological analyses to quickly determine the sources of outbreaks.
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NASP: an accurate, rapid method for the identification of SNPs in WGS datasets that supports flexible input and output formats.
Jason W. Sahl,Jason W. Sahl,Darrin Lemmer,Jason Travis,James M. Schupp,John D. Gillece,Maliha Aziz,Elizabeth M. Driebe,Kevin P. Drees,Nathan D. Hicks,Charles H. D. Williamson,Crystal M. Hepp,David Smith,Chandler C. Roe,David M. Engelthaler,David M. Wagner,Paul Keim +16 more
TL;DR: This study demonstrates how NASP compares with other tools in the analysis of two real bacterial genomics datasets and one simulated dataset and demonstrates differences in results based on the choice of the reference genome and choice of inferring phylogenies from concatenated SNPs or alignments including monomorphic positions.
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Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Nazli Dizman,Luis Meza,Paulo Gustavo Bergerot,Marice B Alcantara,Tanya B. Dorff,Yung Lyou,Paul Frankel,Yujie Cui,Valerie Mira,M. Llamas,JoAnn Hsu,Zeynep Zengin,Nicholas Salgia,Sabrina Salgia,Jasnoor Malhotra,Neal Shiv Chawla,Alexander Chehrazi-Raffle,Ramya Muddasani,John D. Gillece,Laurens Reining,Jeff Trent,Motomichi Takahashi,Kentaro Oka,Seiya Higashi,Marcin Kortylewski,Sarah K. Highlander,Sumanta K. Pal +26 more
TL;DR: In this article , a bifidogenic live bacterial product (CBM588) was proposed to augment the response to checkpoint inhibitors through modulation of the gut microbiome, and the results showed that CBM588 appeared to enhance the clinical outcome in patients with metastatic renal cell carcinoma treated with nivolumab-ipilimumab.
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Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal
David M. Engelthaler,Nathan D. Hicks,John D. Gillece,Chandler C. Roe,James M. Schupp,Elizabeth M. Driebe,Felix Gilgado,Fabian Carriconde,Fabian Carriconde,Luciana Trilles,Luciana Trilles,Carolina Firacative,Popchai Ngamskulrungroj,Popchai Ngamskulrungroj,Elizabeth Castañeda,Márcia dos Santos Lazéra,Marcia S. C. Melhem,Åsa Pérez-Bercoff,Åsa Pérez-Bercoff,Gavin A. Huttley,Tania C. Sorrell,Kerstin Voelz,Kerstin Voelz,Robin C. May,Robin C. May,Matthew C. Fisher,George Richard Thompson,Shawn R. Lockhart,Paul Keim,Paul Keim,Wieland Meyer +30 more
TL;DR: The emergence of distinct populations of Cryptococcus gattii in the temperate North American Pacific Northwest was surprising, as this species was previously thought to be confined to tropical and semitropical regions.