John F. Davis

TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.

TL;DR: A new, low-cost, high throughput reduced representation expression profiling method, L1000, is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.

TL;DR: A systematic library resource of proteomic signatures that measure changes in the reduced-representation phosphoproteome (P100) and changes in epigenetic marks on histones (GCP) is presented and consistent connectivity among cell types revealed cellular responses that transcended lineage and unexpected associations between drugs.

TL;DR: First-of-its-kind public resource of proteomic responses to systematically administered perturbagens demonstrated, which could be leveraged against public domain external datasets to recognize therapeutic hypotheses that are consistent with ongoing clinical trials for the treatment of multiple myeloma and acute lymphocytic leukemia.

TL;DR: In this paper , a novel forensic method was developed to quantitate 39 drugs of toxicological interest for ante-mortem and postmortem analysis using protein precipitation and DPX WAX-S tips with analysis on a Waters® i-class Acquity ultra-performance liquid chromatography with Phenomenex Kinetex® Column (1.7 µm Biphenyl Å, 2.1 ×100 mm) followed by a Waters´ XeVo-TQS tandem mass spectrometer using positive electrospray ionization in multiple reaction monitor mode.