J
John F Mulley
Researcher at Bangor University
Publications - 54
Citations - 1145
John F Mulley is an academic researcher from Bangor University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 13, co-authored 38 publications receiving 942 citations. Previous affiliations of John F Mulley include University of Liverpool & University of Oxford.
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Journal ArticleDOI
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Ingo Braasch,Andrew R. Gehrke,J. Joshua Smith,Kazuhiko Kawasaki,Tereza Manousaki,Jeremy Pasquier,Angel Amores,Thomas Desvignes,Peter Batzel,Julian M. Catchen,Aaron M. Berlin,Michael S. Campbell,Daniel Barrell,Daniel Barrell,Kyle J. Martin,John F Mulley,Vydianathan Ravi,Alison P. Lee,Tetsuya Nakamura,Domitille Chalopin,Shaohua Fan,Dustin J. Wcisel,Cristian Cañestro,Jason Sydes,Felix E.G. Beaudry,Yi Sun,Jana Hertel,Michael J. Beam,Mario Fasold,Mikio Ishiyama,Jeremy Johnson,Steffi Kehr,Marcia Lara,John H. Letaw,Gary W. Litman,Ronda T. Litman,Masato Mikami,Tatsuya Ota,Nil Ratan Saha,Louise Williams,Peter F. Stadler,Han Wang,John S. Taylor,Quenton C. Fontenot,Allyse M. Ferrara,Stephen M. J. Searle,Bronwen Aken,Bronwen Aken,Mark Yandell,Igor Schneider,Jeffrey A. Yoder,Jean-Nicolas Volff,Axel Meyer,Chris T. Amemiya,Byrappa Venkatesh,Peter W. H. Holland,Yann Guiguen,Julien Bobe,Neil H. Shubin,Federica Di Palma,Jessica Alföldi,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,John H. Postlethwait +63 more
TL;DR: In this article, the authors sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD).
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Restriction and Recruitment—Gene Duplication and the Origin and Evolution of Snake Venom Toxins
TL;DR: Transcriptomic analysis of transcriptomic data for body tissues and salivary and venom glands from five species of venomous and nonvenomous reptiles reveals that snake venom does not evolve through the hypothesized process of duplication and recruitment of genes encoding body proteins, and that many proposed venom toxins are in fact expressed in a wide variety of body tissues.
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Breakup of a homeobox cluster after genome duplication in teleosts
TL;DR: It is proposed that this homeobox gene cluster is held together in chordates by the existence of interdigitated control regions that could be separated after locus duplication in the teleost fish.
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Testing the Toxicofera: comparative transcriptomics casts doubt on the single, early evolution of the reptile venom system.
TL;DR: Quantitative transcriptomic analyses of venom and salivary glands and other body tissues in five species of reptile shows that the majority of genes used to support the establishment and expansion of the Toxicofera are in fact expressed in multiple body tissues and most likely represent general maintenance or "housekeeping" genes.
Journal ArticleDOI
When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species
Giulia Zancolli,Juan J. Calvete,Michael D. Cardwell,Harry W. Greene,William K. Hayes,Matthew J. Hegarty,Hans-Werner Herrmann,Andrew T. Holycross,Dominic I. Lannutti,John F Mulley,Libia Sanz,Zachary D. Travis,Joshua R. Whorley,Catharine E. Wüster,Wolfgang Wüster +14 more
TL;DR: It is shown that genomic structural variation at multiple loci underlies extreme geographical variation in venom composition, which is maintained despite extensive gene flow, and how the interplay between genomic architecture and local-scale spatial heterogeneity in selective pressures may facilitate the retention of adaptive functional polymorphisms across a continuous space.