J
John G.F. Cleland
Researcher at National Institutes of Health
Publications - 1276
Citations - 125527
John G.F. Cleland is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heart failure & Ejection fraction. The author has an hindex of 137, co-authored 1172 publications receiving 110227 citations. Previous affiliations of John G.F. Cleland include Northwestern University & Imperial College London.
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Journal ArticleDOI
Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEM.
TL;DR: The BASEL study supports the use of B‐type natriuretic peptide testing to confirm the diagnosis of heart failure in patients presenting with acute dyspnoea and the ESTEEM study showed that the oral thrombin inhibitor ximelagatran plus aspirin was more effective than aspirin alone in the prophylaxis of major cardiovascular events following MI.
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Effects of combined renin-angiotensin-aldosterone system inhibitor and beta-blocker treatment on outcomes in heart failure with reduced ejection fraction: insights from BIOSTAT-CHF and ASIAN-HF registries.
Wouter Ouwerkerk,Tiew-Hwa Katherine Teng,Tiew-Hwa Katherine Teng,Jasper Tromp,Jasper Tromp,Wan Ting Tay,John G.F. Cleland,Dirk J. van Veldhuisen,Kenneth Dickstein,Kenneth Dickstein,Leong L. Ng,Chim C. Lang,Stefan D. Anker,Faiez Zannad,Chung-Lieh Hung,Chung-Lieh Hung,Jitendra P. S. Sawhney,Ajay Naik,Wataru Shimizu,Nobuhisa Hagiwara,Gurpreet Singh Wander,Inder S. Anand,A. Mark Richards,Adriaan A. Voors,Carolyn S.P. Lam,Carolyn S.P. Lam +25 more
TL;DR: This study investigated the association of combined up‐titration of ACEi/ARBs and β‐blockers with all‐cause mortality and its combination with hospitalization for HF.
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Identification of a mutation in the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy.
Sahar Al-Mahdawi,Susan Chamberlain,John G.F. Cleland,Petros Nihoyannopoulos,D. M. Gilligan,Julie French,Lubna Choudhury,Robert Williamson,Celia M. Oakley +8 more
TL;DR: Investigation of the molecular genetic basis of the cause of disease in a family with hypertrophic cardiomyopathy finds a mutation at aminoacid position 908 within exon 23 of the beta cardiac myosin heavy chain gene, resulting in a conversion of a leucine to valine.
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Early vs. late worsening heart failure during acute heart failure hospitalization : Insights from the PROTECT trial
Robert J. Mentz,Robert J. Mentz,Marco Metra,Gad Cotter,Olga Milo,Colleen McKendry,Karen Chiswell,Beth A. Davison,John G.F. Cleland,Daniel M. Bloomfield,Howard C. Dittrich,Mona Fiuzat,Mona Fiuzat,Piotr Ponikowski,Michael M. Givertz,Adriaan A. Voors,John R. Teerlink,Christopher M. O'Connor,Christopher M. O'Connor +18 more
TL;DR: Worsening heart failure symptoms despite initial therapy during admission for acute heart failure is associated with worse outcomes and the intensity of WHF therapy with outcomes is unknown.
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Airway resistance in chronic heart failure measured by impulse oscillometry.
TL;DR: CHF patients have elevated airway resistance and reduced reactance measured with IOS compared with control subjects, which might contribute to exercise intolerance in CHF.