J
John G.F. Cleland
Researcher at National Institutes of Health
Publications - 1276
Citations - 125527
John G.F. Cleland is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heart failure & Ejection fraction. The author has an hindex of 137, co-authored 1172 publications receiving 110227 citations. Previous affiliations of John G.F. Cleland include Northwestern University & Imperial College London.
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Journal ArticleDOI
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.
John G.F. Cleland,John R. Teerlink,Roxy Senior,Evgeny M. Nifontov,John Murray,Chim C. Lang,Vitaly A. Tsyrlin,Barry H. Greenberg,Jamil Mayet,Darrel P. Francis,Tamaz Shaburishvili,Mark J. Monaghan,Mitchell T. Saltzberg,Ludwig Neyses,Scott M. Wasserman,Jacqueline H. Lee,Khalil G. Saikali,Cyril P. Clarke,Jonathan H. Goldman,Andrew A. Wolff,Fady I. Malik +20 more
TL;DR: Omecamtiv mecarbil improved cardiac function in patients with heart failure caused by left ventricular dysfunction and could be the first in class of a new therapeutic agent.
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Effects of enalapril in heart failure: a double blind study of effects on exercise performance, renal function, hormones, and metabolic state.
John G.F. Cleland,H. J. Dargie,Stephen G. Ball,G. Gillen,G. P. Hodsman,James J. Morton,B. W. East,I. Robertson,Ian Ford,J. I. S. Robertson +9 more
TL;DR: On enalapril the improvement in symptoms, exercise performance, fall in plasma noradrenaline, and rise in serum potassium coincided with a decline in the frequency of ventricular extrasystoles recorded during ambulatory monitoring, suggesting that this drug may not be beneficial in early heart failure.
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A systematic review of telemonitoring for the management of heart failure.
TL;DR: Telemonitoring allows a clinician to monitor, on a daily basis, physiological variables measured by patients at home, which provides a means to keep patients with heart failure under close supervision, which could reduce the rate of admission to hospital and accelerate discharge.
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The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure
Klaus K. Witte,Nikolay P. Nikitin,Anita C. Parker,Stephan von Haehling,Hans-Dieter Volk,Stefan D. Anker,Andrew L. Clark,John G.F. Cleland +7 more
TL;DR: Long-term multiple micronutrient supplementation can improve LV volumes and LVEF and QoL scores in elderly patients with heart failure due to LV systolic dysfunction.
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Six minute corridor walk test as an outcome measure for the assessment of treatment in randomized, blinded intervention trials of chronic heart failure: a systematic review.
TL;DR: The 6MWT has not yet been proven to be a robust test for the identification of effective pharmacological interventions although it appears useful for the assessment of cardiac resynchronization therapy.