John G.F. Cleland

TL;DR: The chamber size, wall thickness, and systolic function of the left ventricle are normal in most young Type 1 diabetic patients who have few microvascular complications.

TL;DR: Use of NT-proBNP by PCPs to detect major-LVSD and major-SHD in patients with suspected HF could reduce referrals for specialist HF-assessment, provide cost-avoidance compared to direct referral and improve the efficiency of care.

TL;DR: The beneficial effect of ACE inhibitors on mortality has been established in a series of trials, but in clinical practice, ACE inhibitors are commonly administered in doses much lower than those shown to be effective in the landmark trials.

TL;DR: Cooperative efforts among physicians, clinical trialists, regulators, and sponsors are needed to address unresolved issues including re-defining therapeutic targets that are meaningful to patients with diabetes, determining the appropriate length of follow-up for future trials, and considering the ethical and operational challenges of non-inferiority designs.

TL;DR: In patients suffering from myocardial infarction, NeuropeptideY concentrations peak approximately eight hours after myocardious infarctions and return to thenormal range within two to three days unless heart failure supervenes, in which case theymay become chronically elevated in patientssuffering from heart failure.