J
John G.F. Cleland
Researcher at National Institutes of Health
Publications - 1276
Citations - 125527
John G.F. Cleland is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heart failure & Ejection fraction. The author has an hindex of 137, co-authored 1172 publications receiving 110227 citations. Previous affiliations of John G.F. Cleland include Northwestern University & Imperial College London.
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Journal Article
Cardiovascular responses to verapamil and propranolol in hypertensive patients.
TL;DR: Verapamil + propranolol is an effective antihypertensive combination, but heart rate, atrio-ventricular conduction and left ventricular function may be affected adversely, necessitating careful monitoring of therapy.
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Heart failure treatment up-titration and outcome and age: an analysis of BIOSTAT-CHF.
Ify R. Mordi,Wouter Ouwerkerk,Stefan D. Anker,John G.F. Cleland,Kenneth Dickstein,Kenneth Dickstein,Marco Metra,Leong L. Ng,Nilesh J. Samani,Dirk J. van Veldhuisen,Faiez Zannad,Adriaan A. Voors,Chim C. Lang +12 more
TL;DR: The aim of this study was to evaluate the association of up‐titration of angiotensin‐converting enzyme inhibitors (ACEI), angiotENSin receptor blockers (ARB) and beta‐blockers on outcome across the age spectrum in HFrEF patients.
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No reduction in cardiovascular risk with NSAIDs—including aspirin?
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Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study
Christos V. Bourantas,Nikolay P. Nikitin,Huan P. Loh,Elena I. Lukaschuk,Nassar Sherwi,Ramesh de Silva,Ann C. Tweddel,Mohamed F. Alamgir,Kenneth Wong,Sanjay Gupta,Andrew L. Clark,John G.F. Cleland +11 more
TL;DR: In this cohort of patients with left ventricular systolic dysfunction and ischaemic heart disease, about half of all segments had contractile dysfunction but only one third of these had > 50% of the wall thickness affected by scar, suggesting that most dysfunctional segments could improve in response to an appropriate intervention.
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Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis
TL;DR: Previous studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease, but more evidence is required.