A
Annie S. P. Yang
Researcher at Radboud University Nijmegen
Publications - 19
Citations - 578
Annie S. P. Yang is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 10, co-authored 16 publications receiving 326 citations. Previous affiliations of Annie S. P. Yang include Walter and Eliza Hall Institute of Medical Research & University of Melbourne.
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Journal ArticleDOI
Outcomes of controlled human malaria infection after BCG vaccination.
Jona Walk,L. Charlotte J. de Bree,Wouter Graumans,Rianne Stoter,Geert-Jan van Gemert,Marga van de Vegte-Bolmer,Karina Teelen,Cornelus C. Hermsen,Rob J.W. Arts,Marije C. Behet,Farid Keramati,Simone J.C.F.M. Moorlag,Annie S. P. Yang,Reinout van Crevel,Peter Aaby,Quirijn de Mast,André J. A. M. van der Ven,Christine Stabell Benn,Christine Stabell Benn,Mihai G. Netea,Mihai G. Netea,Robert W. Sauerwein +21 more
TL;DR: It is shown that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.
Journal ArticleDOI
A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.
Lawrence T. Wang,Lais Pereira,Yevel Flores-Garcia,James O’Connor,Barbara J. Flynn,Arne Schön,Nicholas K. Hurlburt,Marlon Dillon,Annie S. P. Yang,Amanda Fabra-García,Azza H. Idris,Bryan T. Mayer,Monica W. Gerber,Raphael Gottardo,Rosemarie D. Mason,Nicole Cavett,Reid B. Ballard,Neville K. Kisalu,Alvaro Molina-Cruz,Jorgen Nelson,Rachel Vistein,Carolina Barillas-Mury,Rogerio Amino,David Baker,Neil P. King,Robert W. Sauerwein,Marie Pancera,Ian A. Cockburn,Fidel Zavala,Joseph R. Francica,Robert A. Seder +30 more
TL;DR: The subdominant PfCSP minor repeats as neutralizing epitopes are defined, an in vitro biophysical correlate of SPZ neutralization is identified, and it is demonstrated that the liver is an important site for antibodies to prevent malaria.
Journal ArticleDOI
Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice
Annie S. P. Yang,Annie S. P. Yang,Matthew T. O'Neill,Charlie Jennison,Charlie Jennison,Sash Lopaticki,Cody C. Allison,Cody C. Allison,Jennifer S. Armistead,Jennifer S. Armistead,Sara M. Erickson,Sara M. Erickson,Kelly L. Rogers,Kelly L. Rogers,Andrew M. Ellisdon,Andrew M. Ellisdon,James C. Whisstock,James C. Whisstock,Rebecca E. Tweedell,Rhoel R. Dinglasan,Donna N. Douglas,Norman M. Kneteman,Justin A Boddey,Justin A Boddey +23 more
TL;DR: It is demonstrated that SPECT and perforin-like protein 1 (PLP1) are critical for transcellular migration by P. falciparum sporozoites and demonstrates the importance of cell traversal for liver infection by this human pathogen.
Journal ArticleDOI
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
Sash Lopaticki,Annie S. P. Yang,Annie S. P. Yang,Annie S. P. Yang,Alan John,Alan John,Nichollas E. Scott,James P. Lingford,Matthew T. O'Neill,Sara M. Erickson,Sara M. Erickson,Nicole C. McKenzie,Nicole C. McKenzie,Charlie Jennison,Charlie Jennison,Lachlan Whitehead,Lachlan Whitehead,Donna N. Douglas,Norman M. Kneteman,Ethan D. Goddard-Borger,Ethan D. Goddard-Borger,Justin A Boddey,Justin A Boddey +22 more
TL;DR: POFUT2 plays a similar role in malaria parasites to that in metazoans: it ensures the trafficking of Plasmodium TSR proteins as part of a non-canonical glycosylation-dependent endoplasmic reticulum protein quality control mechanism.
Journal ArticleDOI
AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver
Annie S. P. Yang,Annie S. P. Yang,Sash Lopaticki,Matthew T. O'Neill,Sara M. Erickson,Sara M. Erickson,Donna N. Douglas,Norman M. Kneteman,Justin A Boddey,Justin A Boddey +9 more
TL;DR: It is shown that AMA1 and MAEBL are important for P. falciparum sporozoites to perform typical functions necessary for infection of human hepatocytes and have important roles during infection at distinct points in the life cycle, including the blood, mosquito, and liver stages.