José María Carazo

TL;DR: The algorithm applied to SOTA is able to not only successfully construct phylogenetic trees of protein families, such as cytochrome c, triosephophate isomerase, and hemoglobin alpha chains, but also classify very diversified sequence data sets,such as a mixture of interleukins and their receptors.

TL;DR: The use of wavelets to match the experimental projections with those obtained from a reference 3D model and the wavelet decomposition of the projection images provides a framework for a multiscale matching algorithm in which speed and robustness to noise are gained.

TL;DR: The molecular and structural characterization of two different types of human adenovirus light particles produced by a mutant with delayed packaging are presented and it is shown that these particles lack core polypeptide V but do not lack the density corresponding to this protein in the X-ray structure, thereby adding support to the adenvirus cryo-electron microscopy model.

TL;DR: Three-dimensional image reconstruction has been applied to electron micrographs of noncrystalline, negatively stained ribosomes obtained from Escherichia coli, showing an overall appearance resembling models that had been derived earlier by direct visual interpretation of electron micro graphs.

TL;DR: Three-dimensional cryo-electron microscopy is used to visualize early events in the activation of DNA replication in the SV40 model system andalyses of LTag C-terminal regions reveal that the LTag hexamers bound to the A/T-rich tract origin of replication and early palindromeorigin of replication elements are structurally distinct.