Josh G. Chenoweth

TL;DR: It is shown that cell lines can be derived from the epiblast, a tissue of the post-implantation embryo that generates the embryo proper, and interrogated to understand how pluripotent cells generate distinct fates during early development.

TL;DR: It is proposed that ubiquitylation regulates TAD function by serving as a dual signal for activation and activator destruction, demonstrating that activator ubiquitylated is essential for transcriptional activation.

TL;DR: The identification of regulatory elements from different cell types is necessary for understanding the mechanisms controlling cell type–specific and housekeeping gene expression and it is found that approximately 8% of the genome overlaps a DNaseI HS site in at least one the six cell lines studied, indicating that a significant percentage of the genomes is potentially functional.

TL;DR: The findings indicate that novel stem cell lines, with unique functional and molecular properties, can be generated from murine blastocyst embryos and demonstrate that the culture growth factor environment and cell-cell interaction play a critical role in defining several unique and stable stem cell ground states.

TL;DR: It is shown that a repressor domain in CoREST interacts with BRG1-associated factor (BAF) 57, a component of the hSWI·SNF complex, and that ATP-dependent chromatin remodeling, as well as histone deacetylation, is needed for REST-mediated repression.