Jun Lu

TL;DR: In this article, a solution-based method for RNA expression profiling, including expression of microRNAs and mRNAs, is proposed. But the method is not suitable for high-throughput, low-cost, and flexible solution.

TL;DR: The sequence of chemical events, platinum binding to the monomeric protein and the induced conformational change and perturbations to the self-association of the monomers, is shown to be important in the cell damaging process.

TL;DR: Only one of the four peptides predicted, PSMA(27), induced CTLs that were effective at recognizing prostate tumor cells expressing the HLA-A2 and PSMA molecules, underline the importance of demonstrating antitumor reactivity of peptide-induced C TLs for the selection of epitopes destined to become immunotherapeutic for prostate cancer.

TL;DR: The most twisted polycyclic aromatic hydrocarbon known, with an end-to-end twist of 143.6 degrees as discussed by the authors, was obtained by the reaction of 1,3-diphenylphenanthro[9,10-c]furan with the bisaryne equivalent generated from 1,2,4,5-tetrabromo-3,6-dimethylbenzene.

TL;DR: In an in vitro model system, the expansion and cytolytic function of tumor-reactive human CTL can be enhanced by CD4(+) helper T lymphocytes through costimulatory signals that are mediated by cell surface molecules.