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Kanako Ishizuka
Researcher at Nagoya University
Publications - 42
Citations - 801
Kanako Ishizuka is an academic researcher from Nagoya University. The author has contributed to research in topics: Autism spectrum disorder & Medicine. The author has an hindex of 11, co-authored 31 publications receiving 473 citations. Previous affiliations of Kanako Ishizuka include Nagoya Institute of Technology.
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Journal ArticleDOI
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights
Itaru Kushima,Branko Aleksic,Masahiro Nakatochi,Teppei Shimamura,Takashi Okada,Yota Uno,Yota Uno,Mako Morikawa,Kanako Ishizuka,Tomoko Shiino,Hiroki Kimura,Yuko Arioka,Akira Yoshimi,Yuto Takasaki,Yanjie Yu,Yukako Nakamura,Maeri Yamamoto,Tetsuya Iidaka,Shuji Iritani,Toshiya Inada,Nanayo Ogawa,Emiko Shishido,Youta Torii,Naoko Kawano,Yutaka Omura,Toru Yoshikawa,Tokio Uchiyama,Toshimichi Yamamoto,Masashi Ikeda,Ryota Hashimoto,Hidenaga Yamamori,Yuka Yasuda,Toshiyuki Someya,Yuichiro Watanabe,Jun Egawa,Ayako Nunokawa,Masanari Itokawa,Makoto Arai,Mitsuhiro Miyashita,Akiko Kobori,Michio Suzuki,Tsutomu Takahashi,Masahide Usami,Masaki Kodaira,Kyota Watanabe,Tsukasa Sasaki,Hitoshi Kuwabara,Mamoru Tochigi,Fumichika Nishimura,Hidenori Yamasue,Yosuke Eriguchi,Seico Benner,Masaki Kojima,Walid Yassin,Toshio Munesue,Shigeru Yokoyama,Ryo Kimura,Yasuko Funabiki,Hirotaka Kosaka,Makoto Ishitobi,Tetsuro Ohmori,Shusuke Numata,Takeo Yoshikawa,Tomoko Toyota,Kazuhiro Yamakawa,Toshimitsu Suzuki,Yushi Inoue,Kentaro Nakaoka,Yu-ichi Goto,Masumi Inagaki,Naoki Hashimoto,Ichiro Kusumi,Shuraku Son,Toshiya Murai,Tempei Ikegame,Naohiro Okada,Kiyoto Kasai,Shohko Kunimoto,Daisuke Mori,Nakao Iwata,Norio Ozaki +80 more
TL;DR: An etiological overlap of ASD and SCZ is suggested and multiple disease-relevant genes in eight well-known ASD/SCZ-associated CNV loci are identified, which provide biological insights into these disorders.
Journal ArticleDOI
Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder.
Atsushi Takata,Noriko Miyake,Yoshinori Tsurusaki,Ryoko Fukai,Satoko Miyatake,Eriko Koshimizu,Itaru Kushima,Takashi Okada,Mako Morikawa,Yota Uno,Kanako Ishizuka,Kazuhiko Nakamura,Kazuhiko Nakamura,Masatsugu Tsujii,Takeo Yoshikawa,Tomoko Toyota,Nobuhiko Okamoto,Yoko Hiraki,Ryota Hashimoto,Yuka Yasuda,Shinji Saitoh,Kei Ohashi,Yasunari Sakai,Shouichi Ohga,Toshiro Hara,Mitsuhiro Kato,Kazuyuki Nakamura,Aiko Ito,Chizuru Seiwa,Emi Shirahata,Hitoshi Osaka,Ayumi Matsumoto,Saoko Takeshita,Jun Tohyama,Tomoko Saikusa,Tomoko Saikusa,Toyojiro Matsuishi,Toyojiro Matsuishi,Takumi Nakamura,Takumi Nakamura,Takashi Tsuboi,Tadafumi Kato,Toshifumi Suzuki,Toshifumi Suzuki,Hirotomo Saitsu,Mitsuko Nakashima,Takeshi Mizuguchi,Fumiaki Tanaka,Norio Mori,Norio Ozaki,Naomichi Matsumoto +50 more
TL;DR: DNMs in 262 ASD probands of Japanese origin are analyzed and the "de novo paradigm" of ASDs across ethnicities is confirmed and a global downregulating effect of valproic acid, a known risk factor for ASDs, is revealed.
Journal ArticleDOI
High-resolution copy number variation analysis of schizophrenia in Japan
Itaru Kushima,Branko Aleksic,Masahiro Nakatochi,Teppei Shimamura,Tomoko Shiino,Akira Yoshimi,Hiroki Kimura,Yuto Takasaki,Chaochen Wang,Jingrui Xing,Kanako Ishizuka,Tomoko Oya-Ito,Yukako Nakamura,Yuko Arioka,T Maeda,Maeri Yamamoto,Mami Yoshida,H Noma,Shuko Hamada,Maki Morikawa,Yota Uno,Takashi Okada,Tetsuya Iidaka,Shuji Iritani,Toshimichi Yamamoto,Mitsuhiro Miyashita,Akiko Kobori,Makoto Arai,Masanari Itokawa,M C Cheng,Y A Chuang,Chia-Hsiang Chen,Michio Suzuki,Tsutomu Takahashi,Ryota Hashimoto,Hidenaga Yamamori,Yuka Yasuda,Yuichiro Watanabe,Ayako Nunokawa,Toshiyuki Someya,Masashi Ikeda,Tomoko Toyota,Takeo Yoshikawa,Shusuke Numata,Tetsuro Ohmori,Shohko Kunimoto,Daisuke Mori,Nakao Iwata,Norio Ozaki +48 more
TL;DR: The study shows the high genetic heterogeneity of SCZ and its clinical features and raises the possibility that genomic instability is involved in its pathogenesis, which may be related to the increased burden of de novo CNVs and variable expressivity of CNVs.
Journal ArticleDOI
Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders.
Jingrui Xing,Hiroki Kimura,Chenyao Wang,Kanako Ishizuka,Itaru Kushima,Yuko Arioka,Akira Yoshimi,Yukako Nakamura,Tomoko Shiino,Tomoko Oya-Ito,Yuto Takasaki,Yota Uno,Takashi Okada,Tetsuya Iidaka,Branko Aleksic,Daisuke Mori,Norio Ozaki +16 more
TL;DR: The results suggest that rare missense mutations in the candidate PSD genes may increase susceptibility to SZ and/or ASD, and may strengthen the theory that rare, non-synonymous variants confer substantial genetic risks for these disorders.
Journal ArticleDOI
Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders.
Kanako Ishizuka,Yoshitaka Fujita,Takeshi Kawabata,Hiroki Kimura,Yoshimi Iwayama,Toshiya Inada,Yuko Okahisa,Jun Egawa,Masahide Usami,Itaru Kushima,Yota Uno,Yota Uno,Takashi Okada,Masashi Ikeda,Branko Aleksic,Daisuke Mori,To Someya,Takeo Yoshikawa,Nakao Iwata,Haruki Nakamura,Toshihide Yamashita,Norio Ozaki +21 more
TL;DR: The results strengthen the association between microglia-specific genes and neurodevelopmental disorders by detecting a statistically significant association between the variant Ala55Thr in CX3CR1 with SCZ and ASD phenotypes.