S
Shusuke Numata
Researcher at University of Tokushima
Publications - 124
Citations - 3734
Shusuke Numata is an academic researcher from University of Tokushima. The author has contributed to research in topics: Medicine & Schizophrenia. The author has an hindex of 32, co-authored 107 publications receiving 2980 citations. Previous affiliations of Shusuke Numata include National Institutes of Health & RIKEN Brain Science Institute.
Papers
More filters
Journal ArticleDOI
DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex
Shusuke Numata,Tianzhang Ye,Tianzhang Ye,Thomas M. Hyde,Thomas M. Hyde,Xavier Guitart-Navarro,Ran Tao,Michael Wininger,Carlo Colantuoni,Carlo Colantuoni,Daniel R. Weinberger,Daniel R. Weinberger,Joel E. Kleinman,Barbara K. Lipska +13 more
TL;DR: The results indicate that promoter DNA methylation in the human PFC is a highly dynamic process modified by genetic variance and regulating gene transcription, which correlates with expression of a subset of genes, including genes involved in brain development and in de novoDNA methylation.
Journal ArticleDOI
Brief assessment of cognition in schizophrenia: validation of the Japanese version.
Yasuhiro Kaneda,Tomiki Sumiyoshi,Richard S.E. Keefe,Yasuhito Ishimoto,Shusuke Numata,Tetsuro Ohmori +5 more
TL;DR: It is indicated that the BACS‐J is a reliable and practical scale to evaluate cognitive function and a principal components analysis with varimax rotation resulted in a three‐factor solution.
Journal ArticleDOI
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights
Itaru Kushima,Branko Aleksic,Masahiro Nakatochi,Teppei Shimamura,Takashi Okada,Yota Uno,Yota Uno,Mako Morikawa,Kanako Ishizuka,Tomoko Shiino,Hiroki Kimura,Yuko Arioka,Akira Yoshimi,Yuto Takasaki,Yanjie Yu,Yukako Nakamura,Maeri Yamamoto,Tetsuya Iidaka,Shuji Iritani,Toshiya Inada,Nanayo Ogawa,Emiko Shishido,Youta Torii,Naoko Kawano,Yutaka Omura,Toru Yoshikawa,Tokio Uchiyama,Toshimichi Yamamoto,Masashi Ikeda,Ryota Hashimoto,Hidenaga Yamamori,Yuka Yasuda,Toshiyuki Someya,Yuichiro Watanabe,Jun Egawa,Ayako Nunokawa,Masanari Itokawa,Makoto Arai,Mitsuhiro Miyashita,Akiko Kobori,Michio Suzuki,Tsutomu Takahashi,Masahide Usami,Masaki Kodaira,Kyota Watanabe,Tsukasa Sasaki,Hitoshi Kuwabara,Mamoru Tochigi,Fumichika Nishimura,Hidenori Yamasue,Yosuke Eriguchi,Seico Benner,Masaki Kojima,Walid Yassin,Toshio Munesue,Shigeru Yokoyama,Ryo Kimura,Yasuko Funabiki,Hirotaka Kosaka,Makoto Ishitobi,Tetsuro Ohmori,Shusuke Numata,Takeo Yoshikawa,Tomoko Toyota,Kazuhiro Yamakawa,Toshimitsu Suzuki,Yushi Inoue,Kentaro Nakaoka,Yu-ichi Goto,Masumi Inagaki,Naoki Hashimoto,Ichiro Kusumi,Shuraku Son,Toshiya Murai,Tempei Ikegame,Naohiro Okada,Kiyoto Kasai,Shohko Kunimoto,Daisuke Mori,Nakao Iwata,Norio Ozaki +80 more
TL;DR: An etiological overlap of ASD and SCZ is suggested and multiple disease-relevant genes in eight well-known ASD/SCZ-associated CNV loci are identified, which provide biological insights into these disorders.
Journal ArticleDOI
GABA concentration in schizophrenia patients and the effects of antipsychotic medication: A proton magnetic resonance spectroscopy study
Shin'Ya Tayoshi,Masahito Nakataki,Satsuki Sumitani,Kyoko Taniguchi,Sumiko Shibuya-Tayoshi,Shusuke Numata,Jun-ichi Iga,Shu-ichi Ueno,Masafumi Harada,Tetsuro Ohmori +9 more
TL;DR: There are no differences in GABA concentrations in the anterior cingulate cortex or the left basal ganglia of schizophrenia patients compared to healthy controls, and this is the first study to have directly measured GABA concentration in schizophrenia patients using (1)H-MRS.
Journal ArticleDOI
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms.
Shusuke Numata,Shu-ichi Ueno,Jun-ichi Iga,Ken Yamauchi,Song Hongwei,Koji Ohta,Sawako Kinouchi,Sumiko Shibuya-Tayoshi,Shin'Ya Tayoshi,Michitaka Aono,Naomi Kameoka,Satsuki Sumitani,Masahito Tomotake,Yasuhiro Kaneda,Takahide Taniguchi,Yasuhito Ishimoto,Tetsuro Ohmori +16 more
TL;DR: The investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment.