K
Kayo Taketa
Researcher at Kumamoto University
Publications - 16
Citations - 607
Kayo Taketa is an academic researcher from Kumamoto University. The author has contributed to research in topics: Diabetes mellitus & Peroxisome proliferator-activated receptor. The author has an hindex of 11, co-authored 16 publications receiving 564 citations.
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Journal ArticleDOI
Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependent Cyclooxygenase-2 Expression in Macrophages
Miyuki Yano,Takeshi Matsumura,Takafumi Senokuchi,Norio Ishii,Yusuke Murata,Kayo Taketa,Hiroyuki Motoshima,Tetsuya Taguchi,Kazuhiro Sonoda,Daisuke Kukidome,Yoh Takuwa,Teruo Kawada,Michael Brownlee,Takeshi Nishikawa,Eiichi Araki +14 more
TL;DR: It is demonstrated that statins inhibited lipopolysaccharide-induced tumor necrosis factor α or monocyte chemoattractant protein-1 mRNA expression, and these effects by statins were abrogated by the PPARγ antagonist T0070907 or by small interfering RNA of PPARβ or PPARα.
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Inherited adrenocorticotropin-independent macronodular adrenal hyperplasia with abnormal cortisol secretion by vasopressin and catecholamines: detection of the aberrant hormone receptors on adrenal gland.
Nobuhiro Miyamura,Tetsuya Taguchi,Yusuke Murata,Kayo Taketa,Shinsuke Iwashita,Kazuya Matsumoto,Takeshi Nishikawa,Tetsushi Toyonaga,Michiharu Sakakida,Eiichi Araki +9 more
TL;DR: An intervention could be tried to prevent the development of overt Cushing’s syndrome by suppression of the possible endogenous ligands or by blockade of the receptors that may be aberrantly expressed in his adrenal glands.
Journal ArticleDOI
Oxidized Low Density Lipoprotein Activates Peroxisome Proliferator-activated Receptor-α (PPARα) and PPARγ through MAPK-dependent COX-2 Expression in Macrophages
Kayo Taketa,Takeshi Matsumura,Miyuki Yano,Norio Ishii,Takafumi Senokuchi,Hiroyuki Motoshima,Yusuke Murata,Shokei Kim-Mitsuyama,Teruo Kawada,Hiroyuki Itabe,Motohiro Takeya,Takeshi Nishikawa,Kaku Tsuruzoe,Eiichi Araki +13 more
TL;DR: Ox-LDL-induced increase in 15d-PGJ2 level through ERK1/2-dependent COX-2 expression is one of the mechanisms of PPARα and PPARγ activation in macrophages, and may control excess atherosclerotic progression.
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Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice
Atsuyuki Tsutsumi,Hiroyuki Motoshima,Tatsuya Kondo,Shuji Kawasaki,Takeshi Matsumura,Satoko Hanatani,Motoyuki Igata,Norio Ishii,Hiroyuki Kinoshita,Junji Kawashima,Kayo Taketa,Noboru Furukawa,Kaku Tsuruzoe,Takeshi Nishikawa,Eiichi Araki +14 more
TL;DR: CR reduced ER stress and improved hepatic insulin action by suppressing JNK-mediated IRS-1 serine-phosphorylation in ob/ob mice.
Journal ArticleDOI
Telmisartan Exerts Antiatherosclerotic Effects by Activating Peroxisome Proliferator-Activated Receptor-γ in Macrophages
Takeshi Matsumura,Hiroyuki Kinoshita,Norio Ishii,Kazuki Fukuda,Hiroyuki Motoshima,Takafumi Senokuchi,Kayo Taketa,Shuji Kawasaki,Tomoko Nishimaki-Mogami,Teruo Kawada,Takeshi Nishikawa,Eiichi Araki +11 more
TL;DR: The molecular basis of the antiatherosclerotic effects of telmisartan in macrophages and apolipoprotein E–deficient mice is investigated and these effects may induce antiatherogenic effects in hypertensive patients.