Kenneth D. Greis

TL;DR: This work reports the insulin-like growth factor 2 mRNA-binding proteins as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence, and identifies IGF2BPs as an additional class of N6-methyladenosine (m 6A) reader proteins.

TL;DR: A direct comparison between 6-acrylamido-4-anilinoquinazoline and an equally potent but reversible analog shows that the irreversible inhibitor has far superior in vivo antitumor activity in a human epidermoid carcinoma xenograft model with no overt toxicity at therapeutically active doses.

TL;DR: Investigating the assembly of HCMV by determining the intracellular trafficking of the abundant tegument protein pp150 (UL32) in productively infected human fibroblasts indicated that pp150 remained within the cytoplasm throughout the replicative cycle of H CMV and accumulated in a stable, juxtanuclear structure late in infection.

TL;DR: Overall, the quinazolines proved superior to previous analogues in terms of aqueous solubility, potency, and in vivo antitumor activity, and one example has been selected for clinical evaluation.

TL;DR: Synthetic glycopeptides were generated and used to demonstrate that O-GlcNAc-modified peptides can be rapidly identified in complex mixtures by HPLC-coupled electrospray mass spectrometry and to conclude that the selectivity and the sensitivity of this method will make it a powerful tool for determining the sites of O- Glc NAc modification on proteins of low abundance such as transcription factors and oncogenes.