K
Koichi Shudo
Researcher at University of Tokyo
Publications - 498
Citations - 16161
Koichi Shudo is an academic researcher from University of Tokyo. The author has contributed to research in topics: Retinoic acid & Retinoic acid receptor. The author has an hindex of 56, co-authored 498 publications receiving 15549 citations. Previous affiliations of Koichi Shudo include National Cancer Research Institute & Tokyo Medical and Dental University.
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Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
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Cytokinin activity of N-phenyl-N′-1, 2,3-thiadiazol-5-ylurea (thidiazuron)
TL;DR: The cytokinin activity of Thidiazuron was similar to that of the highly active N -phenyl- N ′-4-pyridylurea derivatives and to the most active cytokinins of the adenine type.
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Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes
Toshimasa Yamauchi,Hironori Waki,Junji Kamon,Koji Murakami,Kiyoto Motojima,Kajuro Komeda,Hiroshi Miki,Naoto Kubota,Yasuo Terauchi,Atsuko Tsuchida,Nobuyo Tsuboyama-Kasaoka,Naoko Yamauchi,Tomohiro Ide,Wataru Hori,Shigeaki Kato,Masashi Fukayama,Yasuo Akanuma,Osamu Ezaki,Akiko Itai,Ryozo Nagai,Satoshi Kimura,Kazuyuki Tobe,Hiroyuki Kagechika,Koichi Shudo,Takashi Kadowaki +24 more
TL;DR: It is shown that an RXR antagonist and a PPARgamma antagonist decrease triglyceride (TG) content in white adipose tissue, skeletal muscle, and liver, thereby ameliorating HF diet-induced obesity and insulin resistance.
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Mutagenic Principle(s) in Tryptophan and Phenylalanine Pyrolysis Products
Takashi Sugimura,Takashi Kawachi,Minako Nagao,Takie Yahagi,Yuko Seino,Toshihiko Okamoto,Koichi Shudo,Takuo Kosuge,Kuniro Tsuji,Keiji Wakabayashi,Yoichi Iitaka,Akiko Itai +11 more
TL;DR: There is a strong probability that cooked foods in which charred material from proteinous components are produced might play a role in carcinogenesis generally occurring in human, and the correlation between mutagens and carcinogens have been generally accepted in recent investigations.
Journal Article
Differential Effects of Synthetic Nuclear Retinoid Receptor-selective Retinoids on the Growth of Human Non-Small Cell Lung Carcinoma Cells
Shi-Yong Sun,Ping Yue,Marcia I. Dawson,Braham Shroot,Serge Michel,William W. Lamph,Richard A. Heyman,Min Teng,Roshantha A.S. Chandraratna,Koichi Shudo,Waun Ki Hong,Reuben Lotan +11 more
TL;DR: There appeared to be no simple correlation among the histological type of the NSCLC, the levels of nuclear receptors or CRABPs, and the response of the cells to the growth-inhibitory effects of retinoids, but results suggest that several synthetic retinoid do exhibit inhibitory activity against NSCLCs, and some of them may be useful clinically.