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Shigeko Kimura
Researcher at University of Tokyo
Publications - 8
Citations - 9398
Shigeko Kimura is an academic researcher from University of Tokyo. The author has contributed to research in topics: AdipoRon & Adiponectin. The author has an hindex of 5, co-authored 7 publications receiving 8961 citations.
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Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi,Junji Kamon,Yasuhiko Minokoshi,Yoichi M. Ito,Hironori Waki,S. Uchida,Shigeo Yamashita,Mitsuhiko Noda,Shunbun Kita,K Ueki,Koji Eto,Y. Akanuma,Philippe Froguel,Fabienne Foufelle,Pascal Ferré,David Carling,Shigeko Kimura,Ryozo Nagai,Barbara B. Kahn,Takashi Kadowaki +19 more
TL;DR: It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
Journal ArticleDOI
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.
Kazuo Hara,Kazuyuki Tobe,Terumasa Okada,Hiroko Kadowaki,Y. Akanuma,C. Ito,Shigeko Kimura,Takashi Kadowaki +7 more
TL;DR: The results of this study suggested that the PGC-1 gene might be implicated in the pathogenesis of Type II diabetes.
Journal ArticleDOI
Willingness of patients with diabetes to use an ICT-based self-management tool: a cross-sectional study
Tomomi Shibuta,Kayo Waki,Nobuko Tomizawa,Ayumi Igarashi,Noriko Yamamoto-Mitani,Satoko Yamaguchi,Hideo Fujita,Shigeko Kimura,Katsuhito Fujiu,Hironori Waki,Yoshihiko Izumida,Takayoshi Sasako,Masatoshi Kobayashi,Ryo Suzuki,Toshimasa Yamauchi,Takashi Kadowaki,Kazuhiko Ohe +16 more
TL;DR: Willing patients with diabetes may expect ICT-based self-management tools to complement outpatient visits and to make self- management easier, and starting with patients who display the willingness factors might optimize programs based on such tools.
Journal ArticleDOI
DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients on Insulin Injections.
Kayo Waki,Katuhito Fujiu,Aki Hayashi,Shigeko Kimura,Haruka Kobayashi,Masaomi Nangaku,Takashi Kadowaki,Kazuhiko Ohe +7 more
TL;DR: A real-time automated interactive system to help patients achieve self-management by type 2 diabetes patients on insulin injections was developed and the safety and usability of the system was assessed.