R
R. Nagai
Researcher at University of Tokyo
Publications - 30
Citations - 7212
R. Nagai is an academic researcher from University of Tokyo. The author has contributed to research in topics: Protein kinase C & Endothelin 1. The author has an hindex of 15, co-authored 30 publications receiving 6957 citations.
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Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
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Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.
Yukiko Kurihara,H. Kurihara,Hiroshi Suzuki,Hiroshi Suzuki,Tatsuhiko Kodama,Kouji Maemura,R. Nagai,Hideaki Oda,Tomoyuki Kuwaki,W. H. Cao,Nobuo Kamada +10 more
TL;DR: It is suggested that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.
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Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
Tsutomu Yamazaki,Kazuyuki Tobe,Eitetsu Hoh,Kouji Maemura,T Kaida,Issei Komuro,Hiroyuki Tamemoto,Takashi Kadowaki,R. Nagai,Yoshio Yazaki +9 more
TL;DR: It is concluded that myocyte stretching increases the activities of MAP kinase and S6 peptide kinase, which may play an important role in the induction of the specific genes and the increase in the protein synthesis.
Journal ArticleDOI
Developmentally regulated expression of vascular smooth muscle myosin heavy chain isoforms.
Makoto Kuro-o,R. Nagai,Hidetsugu Tsuchimochi,Hirohisa Katoh,Yoshio Yazaki,Akiyuki Ohkubo,Fumimaro Takaku +6 more
TL;DR: It is concluded that expression of SM1 and SM2 are differentially regulated during development and that a third type of MHC isoform may exist in embryonic and perinatal vascular smooth muscles.
Journal Article
Expression of intercellular adhesion molecule-1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules.
Tsutomu Yamazaki,Yoshinori Seko,Takuya Tamatani,M Miyasaka,Hideo Yagita,Ko Okumura,R. Nagai,Yoshio Yazaki +7 more
TL;DR: It is found that within 2 hours after reperfusion leukocytes began to infiltrate into the rat myocardia subjected to 30 minutes of ischemia and it is clarified, for the first time, that the expression of intercellular adhesion molecule-1 was enhanced on the capillary and venous endothelial cells from 8 to 96 hours after the start of reperfusions.