K
Kristina Hettne
Researcher at Leiden University Medical Center
Publications - 67
Citations - 1636
Kristina Hettne is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Workflow & Metadata. The author has an hindex of 21, co-authored 64 publications receiving 1306 citations. Previous affiliations of Kristina Hettne include Leiden University & Maastricht University.
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Journal ArticleDOI
A dictionary to identify small molecules and drugs in free text
Kristina Hettne,Rob H. Stierum,Martijn J. Schuemie,Peter J. M. Hendriksen,Bob J. A. Schijvenaars,Erik M. van Mulligen,Jos C. S. Kleinjans,Jan A. Kors +7 more
TL;DR: A dictionary for the identification of small molecules and drugs in text, combining information from UMLS, MeSH, ChEBI, DrugBank, KEGG, HMDB and ChemIDplus is developed.
Journal ArticleDOI
FAIR principles : interpretations and implementation considerations
Annika Jacobsen,Ricardo de Miranda Azevedo,Nick Juty,Dominique Batista,Simon J. Coles,Ronald Cornet,Mélanie Courtot,Mercè Crosas,Michel Dumontier,Chris T. Evelo,Carole Goble,Giancarlo Guizzardi,Karsten Kryger Hansen,Ali Hasnain,Kristina Hettne,Jaap Heringa,Rob Hooft,Melanie Imming,Keith G. Jeffery,Rajaram Kaliyaperumal,Martijn G. Kersloot,Christine Kirkpatrick,Tobias Kuhn,Ignasi Labastida,Barbara Magagna,Peter McQuilton,Natalie Meyers,Annalisa Montesanti,Mirjam van Reisen,Philippe Rocca-Serra,Robert Pergl,Susanna-Assunta Sansone,Luiz Olavo Bonino da Silva Santos,Juliane Schneider,George Strawn,Mark Thompson,Mark Thompson,Andra Waagmeester,Tobias Weigel,Mark Wilkinson,Egon Willighagen,Peter Wittenburg,Marco Roos,Barend Mons,Erik Anthony Schultes +44 more
TL;DR: The concept of FAIR implementation considerations is introduced to assist accelerated global participation and convergence towards accessible, robust, widespread and consistent FAIR implementations.
Journal ArticleDOI
Using a suite of ontologies for preserving workflow-centric research objects
Khalid Belhajjame,Jun Zhao,Daniel Garijo,Matthew Gamble,Kristina Hettne,Raul Palma,Eleni Mina,Oscar Corcho,Jose Manuel Gomez-Perez,Sean Bechhofer,Graham Klyne,Carole Goble +11 more
TL;DR: A novel approach to the preservation of scientific workflows through the application of research objects-aggregations of data and metadata that enrich the workflow specifications that support the creation of workflow-centric research objects.
Proceedings ArticleDOI
Why workflows break — Understanding and combating decay in Taverna workflows
Jun Zhao,Jose Manuel Gomez-Perez,Khalid Belhajjame,Graham Klyne,Esteban García-Cuesta,Aleix Garrido,Kristina Hettne,Marco Roos,David De Roure,Carole Goble +9 more
TL;DR: A minimal set of auxiliary resources to be preserved together with the workflows as an aggregation object and provide a software tool for end-users to create such aggregations and to assess their completeness.
Journal ArticleDOI
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model
Lodewijk J.A. Toonen,Maurice Overzier,Melvin M. Evers,Leticia G. Leon,Sander A.J. van der Zeeuw,Hailiang Mei,Szymon M. Kielbasa,Jelle J. Goeman,Kristina Hettne,Olafur T. Magnusson,Marion Poirel,Alexandre Seyer,Peter A C 't Hoen,Peter A C 't Hoen,Willeke M. C. van Roon-Mom +14 more
TL;DR: The observed transcriptional changes inSCA3 mouse brain reveal parallels with previous reported neuropathology in patients, but also shows brain region specific effects as well as involvement of adrenergic signalling and CREB pathway changes in SCA3.