L
Leonard L. Heston
Researcher at University of Washington
Publications - 42
Citations - 2133
Leonard L. Heston is an academic researcher from University of Washington. The author has contributed to research in topics: Gene & Missense mutation. The author has an hindex of 23, co-authored 42 publications receiving 2098 citations. Previous affiliations of Leonard L. Heston include Hennepin County Medical Center.
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Journal ArticleDOI
Apolipoprotein E genotype and Alzheimer's disease
Shigeji Noguchi,Kaori Murakami,Nobuhiro Yamada,Haydeh Payami,J. A. Kaye,Leonard L. Heston,Thomas D. Bird,Gerard D. Schellenberg +7 more
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MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism.
Akane Shibayama,Edwin H. Cook,Jinong Feng,Cecile Glanzmann,Jin Yan,Nicholas John Craddock,Ian Jones,David Goldman,Leonard L. Heston,Steve S. Sommer +9 more
TL;DR: DNA samples from individuals with schizophrenia and other psychiatric diseases were scanned in order to explore whether the phenotypic spectrum of mutations in the MECP2 gene can extend beyond the traditional diagnoses of RTT in females and severe neonatal encephalopathy in males.
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Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor.
Gobinda Sarkar,Stephen Kapelner,David K. Grandy,Mark Marchionni,Olivier Civelli,Janet L. Sobell,Leonard L. Heston,Steve S. Sommer +7 more
TL;DR: No structural changes were found, suggesting that alteration in the structure of the dopamine D2 receptor is not commonly involved in the etiology of schizophrenia, but two common and one uncommon intragenic polymorphisms were found.
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Evaluation of Neuroleptic Drug Use by Nursing Home Elderly Under Proposed Medicare and Medicaid Regulations
Judith Garrard,Lukas Makris,Trudy Dunham,Leonard L. Heston,Susan L. Cooper,Edward Ratner,Daniel Zelterman,Robert L. Kane +7 more
TL;DR: This study used extant data to estimate ineligible neuroleptic use at the individual and nursing home levels had these regulations been in effect in 1976 through 1985.
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Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples
Michael E. Talkowski,Howard Seltman,Anne S. Bassett,Linda M. Brzustowicz,Xiangning Chen,Kodavali V. Chowdari,David A. Collier,Quirino Cordeiro,Aiden Corvin,Smita N. Deshpande,Michael F. Egan,Michael Gill,Kenneth S. Kendler,George Kirov,Leonard L. Heston,Pat Levitt,David A. Lewis,Tao Li,Karoly Mirnics,Derek W. Morris,Nadine Norton,Michael Conlon O'Donovan,Michael John Owen,Christian Richard,Prachi Semwal,Janet L. Sobell,David St. Clair,Richard E. Straub,B.K. Thelma,Homero Vallada,Daniel R. Weinberger,Nigel Williams,Joel Wood,Feng Zhang,Bernie Devlin,Vishwajit L. Nimgaonkar +35 more
TL;DR: A collaborative meta-analysis using both published and unpublished family-based and case-control samples to resolve the role for RGS4 in SCZ susceptibility suggests risk due to at least two common haplotypes in the presence of heterogeneity.